Non-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder

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dc.contributor.authorErdem, Gokmen U.
dc.contributor.authorDogan, Mutlu
dc.contributor.authorSakin, Abdullah
dc.contributor.authorOruc, Zeynep
dc.contributor.authorYaman, Emel
dc.contributor.authorCinkir, Havva Yesil
dc.contributor.authorUysal, Mukremin
dc.date.accessioned2024-04-24T17:14:29Z
dc.date.available2024-04-24T17:14:29Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The clinicopathological characteristics, treatment modalities, and effects on the prognosis of pure squamous cell carcinoma (SqCC) and adenocarcinoma (AC) were evaluated. Materials and Methods: 86 patients with pure SqCC and AC bladder cancer were evaluated retrospectively. Results: Of the 86 patients, 51 had SqCC and 35 had AC. No differences in clinicopathological characteristics were observed between patients with AC and SqCC, except for the prevalence of T4 disease (28.6% vs. 51.0%, respectively). In multivariate analysis, older age, stage IV disease, and Eastern Cooperative Oncology Group (ECOG) performance status (> 2) were predictive of a poor overall survival (OS). The median OS was significantly longer for stage I-III patients (82.9 months) treated with surgery +/- chemotherapy (CT) +/- radiotherapy (RT) than for those treated with transurethral resection +/- CT +/- RT (24.3 months) (P = 0.007). The median OS of patients with SqCC and AC who were given platinum-based CT for metastasis was 7.7 and 30.3 months, respectively. Conclusions: Advanced age, stage IV disease, and poor ECOG performance status were factors associated with a poor prognosis. Surgery +/- CT +/- RT resulted in significantly better OS, except in stage IV disease. Patients with metastatic AC had better response rates with platinum- based CT. (c) 2018 S. Karger GmbH, Freiburgen_US
dc.identifier.doi10.1159/000486598
dc.identifier.endpage225en_US
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.issue4en_US
dc.identifier.pmid29558755
dc.identifier.scopus2-s2.0-85044358964
dc.identifier.scopusqualityQ3
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.1159/000486598
dc.identifier.urihttps://hdl.handle.net/11468/17988
dc.identifier.volume41en_US
dc.identifier.wosWOS:000430115300010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncology Research and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Urothelialen_US
dc.subjectBladder Canceren_US
dc.subjectAdenocarcinomaen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.titleNon-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladderen_US
dc.titleNon-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder
dc.typeArticleen_US

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