Histopathological and Biochemical Effects of Ecballium elaterium on Sepsis-Induced Lung Injury

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dc.contributor.authorDemir, Melike
dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorKaya, Halide
dc.contributor.authorEkinci, Aysun
dc.contributor.authorArslan, Demet
dc.contributor.authorAslan, Emel
dc.contributor.authorKeles, Aysenur
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate the role of Ecballium elaterium (EE) on sepsis-induced lung injury. Materials and Methods: A total of 30 male rats were divided into three groups as follows: control, sepsis, and treatment groups (sepsis + EE) with each group containing 10 rats. A rat model of sepsis induced by cecal ligation and puncture (CLP) was used. In the treatment group, rats were injected intraperitoneally with 2.5mg/kg EE after CLP. Interleukin-6 (IL-6), tumor necrosis factor (TNF)-, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values after a 24-hr period were measured via cardiac puncture. Animals were harvested after the procedure and biochemical analysis was done and histopathological changes of the tissue sections of lungs were examined thereafter. Results: A statistically significant decrease was observed in the IL-6 (p < .05), TNF- (p < .05), and TOS (p < .01) levels in the sera of the treatment group compared to those of the sepsis group. Following the treatment, the TOS (p = .01) and OSI (p < .05) levels in the lung tissue of rats indicated a statistically significant decrease compared to those of the sepsis group. The histopathological follow-up undertaken after the administration of the EE treatment to septic rats showed significantly lower values of alveolar wall thickness (p < .001), interstitial edema (p = .018), and neutrophil infiltration (p = .047). Conclusion: EE treatment may have beneficial effects on sepsis-induced lung injury, and therefore has potential for clinical use.en_US
dc.identifier.doi10.3109/08941939.2015.1111474
dc.identifier.endpage308en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue5en_US
dc.identifier.pmid26822342
dc.identifier.scopus2-s2.0-84958039008
dc.identifier.scopusqualityQ1
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.3109/08941939.2015.1111474
dc.identifier.urihttps://hdl.handle.net/11468/19078
dc.identifier.volume29en_US
dc.identifier.wosWOS:000384017200009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEcballium Elateriumen_US
dc.subjectSepsisen_US
dc.subjectRaten_US
dc.subjectLungen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleHistopathological and Biochemical Effects of Ecballium elaterium on Sepsis-Induced Lung Injuryen_US
dc.titleHistopathological and Biochemical Effects of Ecballium elaterium on Sepsis-Induced Lung Injury
dc.typeArticleen_US

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