Expression of CD44 and E-cadherin cell adhesion molecules in hypertrophied bladders during chronic partial urethral obstruction and after release of partial obstruction in rats

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dc.contributor.authorOzturk, H
dc.contributor.authorOzturk, H
dc.contributor.authorGuneli, E
dc.contributor.authorYagmur, Y
dc.contributor.authorBuyukbayram, H
dc.date.accessioned2024-04-24T16:18:33Z
dc.date.available2024-04-24T16:18:33Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives. To determine the functional changes in the bladder and the expression of adhesion molecules in bladder tissue during chronic partial urethral obstruction and after release of partial obstruction in rats. Methods. Twenty-one male Sprague-Dawley rats were separated into three groups, each containing 7 rats. A sham operation was performed in group 1 and cystometry was done 6 weeks later. In groups 2 and 3, hypertrophied unstable bladders were developed by partial infravesical outflow obstruction during a 6-week period. After this period, cystometry was performed in all group 2 rats. In group 3, the ligature was removed, the rats were followed up for 6 weeks, and then cystometry was performed. After cystometric evaluation, the bladders in all the rats were removed, weighed, and studied immunohistopathologically. Results. After release of infravesical outflow obstruction, the bladder weight, residual volume, bladder capacity, maximal voiding pressure, voiding amplitude, and bladder contraction time decreased and bladder compliance increased in group 3 compared with group 2. CD44 and E-cadherin expression in the interstitial space and uroepithelial bladder tissue in group 2 rats stained intensely compared with those of groups 1 and 3. Conclusions. After release of 6 weeks of infravesical outflow obstruction, the cystometric parameters were significantly improved. Expression of CD44 and E-cadherin in the obstructed bladder tissue may be a pathologic sign of inflammation.(c) 2005 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2004.12.006
dc.identifier.endpage1018en_US
dc.identifier.issn0090-4295
dc.identifier.issue5en_US
dc.identifier.pmid15882755
dc.identifier.scopus2-s2.0-18844395366
dc.identifier.scopusqualityQ2
dc.identifier.startpage1013en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2004.12.006
dc.identifier.urihttps://hdl.handle.net/11468/16167
dc.identifier.volume65en_US
dc.identifier.wosWOS:000229138800040
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleExpression of CD44 and E-cadherin cell adhesion molecules in hypertrophied bladders during chronic partial urethral obstruction and after release of partial obstruction in ratsen_US
dc.titleExpression of CD44 and E-cadherin cell adhesion molecules in hypertrophied bladders during chronic partial urethral obstruction and after release of partial obstruction in rats
dc.typeArticleen_US

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