Expression of interleukin-17 in lesions of erythema multiforme may indicate a role for T helper 17 cells

Basit Öğe Kaydı
dc.contributor.authorAkkurt, Zeynep Meltem
dc.contributor.authorUcmak, Derya
dc.contributor.authorTurkcu, Gul
dc.contributor.authorYuksel, Hatice
dc.contributor.authorYildiz, Kenan
dc.contributor.authorArica, Mustafa
dc.date.accessioned2024-04-24T17:24:52Z
dc.date.available2024-04-24T17:24:52Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study was to evaluate levels of interleukin (IL)-2, IL-6, IL-8, IL-10, IL-17A and interferon gamma (IFN-gamma) in the serum of patients with erythema multiforme (EM) and to search for the presence of IL-17-expressing cells in lesional samples of EM. Material and methods: A total of 32 patients (22 females and 10 males) diagnosed with EM of the minor or major type were included in the study. Levels of IL-2, IL-6, IL-8, IL-10, IL-17A and IFN-gamma in the serum were determined and compared with healthy controls. Biopsy specimens were stained with haematoxylin and eosin (HE) and monoclonal antibodies to CD4, CD8 and IL-17 for immunohistochemical examination. Results: IL-2, 6, 8 and 17A were significantly higher in the patient group (p = 0.016, p = 0.001, p = 0.004, p = 0.006, respectively) and levels of IL-10 were significantly lower than in the control group (p = 0.046). The cellular infiltrate in lesions of EM was composed mainly of CD4+ T lymphocytes. The presence of IL-17-expressing cells, at proportion of 5 to 50%, was observed in the infiltrate. Conclusions: The demonstration of IL-17-expressing cells in lesions of EM in this study has brought forth the assumption that Th17 cells may be involved in the pathogenesis of EM.en_US
dc.description.sponsorshipDicle University Scientific Projects Commission [12-TF- 130]en_US
dc.description.sponsorshipThis project was supported by grants from the Dicle University Scientific Projects Commission (grant number: 12-TF- 130).en_US
dc.identifier.doi10.5114/ceji.2014.45950
dc.identifier.endpage376en_US
dc.identifier.issn1426-3912
dc.identifier.issn1644-4124
dc.identifier.issue3en_US
dc.identifier.pmid26155150
dc.identifier.scopus2-s2.0-84907966488
dc.identifier.scopusqualityQ3
dc.identifier.startpage370en_US
dc.identifier.urihttps://doi.org/10.5114/ceji.2014.45950
dc.identifier.urihttps://hdl.handle.net/11468/19861
dc.identifier.volume39en_US
dc.identifier.wosWOS:000344202400017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofCentral European Journal of Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErythema Multiformeen_US
dc.subjectT Helper 17en_US
dc.subjectT Helper 1en_US
dc.subjectInterleukin-17en_US
dc.titleExpression of interleukin-17 in lesions of erythema multiforme may indicate a role for T helper 17 cellsen_US
dc.titleExpression of interleukin-17 in lesions of erythema multiforme may indicate a role for T helper 17 cells
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu