Changes in serum desnutrin levels in patients with acne vulgaris

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dc.contributor.authorDemir, Betul
dc.contributor.authorUcak, Haydar
dc.contributor.authorCicek, Demet
dc.contributor.authorAydin, Suleyman
dc.contributor.authorErden, Filter
dc.contributor.authorDertlioglu, Selma Bakar
dc.date.accessioned2024-04-24T17:18:14Z
dc.date.available2024-04-24T17:18:14Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Androgens and insulin may contribute to increased sebum production in the pathogenesis of acne vulgaris. Objective: We investigated the association between serum desnutrin levels and acne vulgaris in the pathogenesis of insulin resistance. Material and methods: 25 patients presenting with acne vulgaris and 25 control subjects participated in this study. Fasting blood glucose, triglycerides, LDL, VLDL, HDL, total cholesterol, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Desnutrin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Results: Patients with acne vulgaris had a mean serum desnutrin level of (8.83 +/- 1.13 mu IU/mL), which was statistically significantly lower in the control group (10:58 +/- 3.43 mu IU/mL). In patients with acne vulgaris the serum glucose levels, insulin levels and HOMA-IR values (87.92 +/- 7:46 mg/dL, 11.33 +/- 5.93 mu IU/mL, 2.49 +/- 1.40, respectively) were significantly higher than the control group (77.36 +/- 9.83 mg/dL, 5.82 +/- 2.68 mu IU/mL, 1.11 +/- 0.51, respectively) (p = 0.01, p<0.001, p<0.001, p<0.001, respectively). Conclusion: Full cohort (patients and controls) evaluation revealed a negative correlation between the serum glucose and desnutrin levels (r = -0.31, p<0.05). A positive correlation was found between insulin and desnutrin levels (r = 0.42, p<0.001). In patients with acne vulgaris, as a result of increased levels of serum glucose and insulin, the function of desnutrin was suppressed, perhaps contributing to insulin resistance.en_US
dc.identifier.doi10.1684/ejd.2014.2405
dc.identifier.endpage593en_US
dc.identifier.issn1167-1122
dc.identifier.issn1952-4013
dc.identifier.issue5en_US
dc.identifier.pmid25152512
dc.identifier.scopus2-s2.0-84919394158
dc.identifier.scopusqualityQ3
dc.identifier.startpage589en_US
dc.identifier.urihttps://doi.org/10.1684/ejd.2014.2405
dc.identifier.urihttps://hdl.handle.net/11468/18679
dc.identifier.volume24en_US
dc.identifier.wosWOS:000347867700009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJohn Libbey Eurotext Ltden_US
dc.relation.ispartofEuropean Journal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne Vulgarisen_US
dc.subjectAcne Dieten_US
dc.subjectDesnutrinen_US
dc.subjectInsulin Resistanceen_US
dc.titleChanges in serum desnutrin levels in patients with acne vulgarisen_US
dc.titleChanges in serum desnutrin levels in patients with acne vulgaris
dc.typeArticleen_US

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