Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide plus desogestrel/ethinyl estradiol combination

Basit Öğe Kaydı
dc.contributor.authorBahceci, M
dc.contributor.authorBilge, M
dc.contributor.authorTuzcu, A
dc.contributor.authorTuzcu, S
dc.contributor.authorBahceci, S
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Prostate-specific antigen (PSA) is expressed in many female tissues and its concentrations were higher in hirsute subjects. We aimed to determine serum PSA level in hirsute women and evaluate the effect of flutamide+ desogestrel/ethynil estradiol combination. Subjects and study design: Thirty patients with polycystic ovary syndrome (PCOS) and 30 healthy controls were studied. Hirsutism was defined by modified Ferriman-Gallwey score (FGS). Free androgen index (FAI) was used for hyperandrogenism. Patients received flutamide (500 mg/d) and oral contraceptive (desogestrel+ethinyl estradiol) for 9 months. Results: Mean FGS (p<0.0001), insulin (p<0.01), FAI (0.0001), androstenedione (p<0.0001), LH (p<0.05), and free testosterone (p<0.003) levels of patients with PCOS were higher than the control group. Mean serum total and free PSA level of PCOS patients were higher than the control group (p<0.0001 and p<0.0001). We found a positive correlation between total PSA levels and FGS (r=0.568, p<0.001), FAI and FGS (r=0.456 and p<0.01). There was also a positive correlation between FAI and total PSA (r=0.503 and p<0.005). At the end of treatment, FGS, androstenedione, free and total testosterone, FAI, serum PSA and LH levels decreased significantly [serum total PSA was 0,0208 +/- 0,0178 ng/ml at baseline and 0,0061 +/- 0,0044 ng/ml after treatment (p<0.0001)]. Conclusions: 1. Serum prostate specific antigen level is higher in patients with PCOS; 2. There is a positive correlation among FGS, FAI and PSA levels; 3. Serum PSA levels decrease with antiandrogen treatment; 4. Serum PSA measurement might be a marker for hirsutism. (C) 2004, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03351061
dc.identifier.endpage356en_US
dc.identifier.issn0391-4097
dc.identifier.issue4en_US
dc.identifier.pmid15233555
dc.identifier.scopus2-s2.0-2942588868
dc.identifier.scopusqualityQ1
dc.identifier.startpage353en_US
dc.identifier.urihttps://doi.org/10.1007/BF03351061
dc.identifier.urihttps://hdl.handle.net/11468/14213
dc.identifier.volume27en_US
dc.identifier.wosWOS:000221739500010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Specific Antigenen_US
dc.subjectFree Androgen Indexen_US
dc.subjectFerriman-Gallwey Scoreen_US
dc.subjectFlutamide And Desogestrel/Ethinyl Estradiolen_US
dc.titleSerum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide plus desogestrel/ethinyl estradiol combinationen_US
dc.titleSerum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide plus desogestrel/ethinyl estradiol combination
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu