Herbal infusions of black seed and wheat germ oil: Their chemical profiles, in vitro bio-investigations and effective formulations as Phyto-Nanoemulsions

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dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorGuler, Emine
dc.contributor.authorDemir, Bilal
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorYavuz, Murat
dc.contributor.authorColpankan, Dilara
dc.contributor.authorSenisik, A. Murat
dc.date.accessioned2024-04-24T16:11:07Z
dc.date.available2024-04-24T16:11:07Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe reported studies related to black seed oil (BSO) and wheat germ oil (WGO) have illustrated that they have a wide range of biological activities. Therefore, enhancing the amount of bio-active compounds that caused higher cell based anti-oxidative effect as well as cell proliferation, etc. in seed oils, infusion of crude plant material has been gained importance as a traditional technique. Herein, we accomplished the infusion of Calendula flowers that also contains many phyto-constituents into BSO and WGO. After the infusion of oils, the change of phytochemical amount was investigated and evaluated according to the oils by chromatography, radical scavenging activity. Subsequently, for investigating the biological impact upon live cells, cytotoxicity, cell-based antioxidant capacity, wound healing and radioprotective activity were tested with monkey kidney fibroblast like cells (Vero) and HaCaT keratinocytes. In vitro cell based experiments (wound healing and radioprotective activity) confirmed that Calendula infused BSO and WGO have greater bio-activity when compared to those plain forms. The herbal oils prepared with an effective extraction technique were incorporated into nanoemulsion systems which will be then called as 'Phyto-Nanoemulsion'. After herbal oil biomolecules were encapsulated into nanoemulsion based delivery systems, the designed formulations were investigated in terms of biological activities. In conclusion, these preparations could be a good candidate as a part of dermal cosmetic products or food supplements which have the therapeutic efficiency, especially after radio- or chemotherapy. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipIndustrial Thesis Support Program (SAN-TEZ) of Republic of Turkey; Ministry of Science, Industry and Technology [0395.STZ.2013-2]; Ege University Scientific Research Projects [2013/FEN/023, 2013/FEN/022]; Ege University, Aliye USTER Foundation; EGE LS (Turkey)en_US
dc.description.sponsorshipThis study was funded by Industrial Thesis Support Program (SAN-TEZ) of Republic of Turkey, Ministry of Science, Industry and Technology (Project Grant No: 0395.STZ.2013-2). And also this work was partially supported by Ege University Scientific Research Projects (2013/FEN/023 and 2013/FEN/022). Ege University, Aliye USTER Foundation was also acknowledged for the research grants. Authors were grateful to WATERS Corp. for supplying UPLC system. Prof. Dr. H. Armagan ARICAN was acknowledged for the fruitful support in the radioprotective activity experiments. EGE LS (Turkey) is acknowledged for their financial support during this work. Also, we thanked to Prof. Emine Bayram and Prof. Akin Olgun from Ege University, Faculty of Agriculture for support in determination of cultivation conditions of organically grown Calendula officinalis.en_US
dc.identifier.doi10.1016/j.colsurfb.2015.05.044
dc.identifier.endpage80en_US
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid26087391
dc.identifier.scopus2-s2.0-84936804811
dc.identifier.scopusqualityQ1
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2015.05.044
dc.identifier.urihttps://hdl.handle.net/11468/15271
dc.identifier.volume133en_US
dc.identifier.wosWOS:000359172600011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHerbal Infusionen_US
dc.subjectCalendulaen_US
dc.subjectBlack Seed Oilen_US
dc.subjectWheat Germ Oilen_US
dc.subjectNanoemulsion Based Carrieren_US
dc.subjectIn Vitro Cell Cultureen_US
dc.titleHerbal infusions of black seed and wheat germ oil: Their chemical profiles, in vitro bio-investigations and effective formulations as Phyto-Nanoemulsionsen_US
dc.titleHerbal infusions of black seed and wheat germ oil: Their chemical profiles, in vitro bio-investigations and effective formulations as Phyto-Nanoemulsions
dc.typeArticleen_US

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