Normocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidism

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dc.contributor.authorTuna, Mazhar Muslum
dc.contributor.authorCaliskan, Mustafa
dc.contributor.authorUnal, Mustafa
dc.contributor.authorDemirci, Taner
dc.contributor.authorDogan, Bercem Aycicek
dc.contributor.authorKucukler, Kerim
dc.contributor.authorOzbek, Mustafa
dc.date.accessioned2024-04-24T16:01:58Z
dc.date.available2024-04-24T16:01:58Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractNormocalcemic primary hyperparathyroidism (NC-PHPT) is a variant of hyperparathyroidism, characterized by normal serum calcium levels, high parathyroid hormone (PTH) and normal 25-OH vitamin D status. The present study aimed to compare complications related to hyperparathyroidism in patients with NC-PHPT and hypercalcemic PHPT (HC-PHPT). We retrospectively evaluated the records of 307 PHPT patients between January 2010 and March 2013. We excluded patients with impaired renal function and liver failure. All patients underwent a biochemical and hormonal examination including serum glucose, albumin, total calcium, phosphorus, creatinine, lipoproteins, PTH and 25-OH vitamin D. Nephrolithiasis and bone mineral density were documented based on a review of the medical records. The study population consisted of 36 (12 %) males and 271 (88 %) females with a mean age of 53.3 +/- A 9.5 years (29-70 years). Twenty-three of the patients were diagnosed with NC-PHPT (group 1) and 284 were diagnosed with HC-PHPT (group 2). There were no significant differences in terms of age, gender, prevalence of hypertension, low bone mineral density and kidney stones between the groups. The mean thyroid-stimulating hormone (TSH) and low-density lipoprotein (LDL) levels were significantly higher in group 1 than in group 2. Our study found that patients with NC-PHPT have similar several complications as patients with HC-PHPT. NC-PHPT patients have higher TSH levels despite being within the normal range, and higher LDL-C levels than patients with HC-PHPT. However, this relationship needs to be clarified in future studies with larger cohorts.en_US
dc.identifier.doi10.1007/s00774-015-0673-3
dc.identifier.endpage335en_US
dc.identifier.issn0914-8779
dc.identifier.issn1435-5604
dc.identifier.issue3en_US
dc.identifier.pmid26056016
dc.identifier.scopus2-s2.0-84930599652
dc.identifier.scopusqualityQ1
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1007/s00774-015-0673-3
dc.identifier.urihttps://hdl.handle.net/11468/14538
dc.identifier.volume34en_US
dc.identifier.wosWOS:000374568400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJournal of Bone and Mineral Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary Hyperparathyroidismen_US
dc.subjectNormocalcemiaen_US
dc.subjectKidney Stonesen_US
dc.subjectOsteoporosisen_US
dc.subjectParathormoneen_US
dc.titleNormocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidismen_US
dc.titleNormocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidism
dc.typeArticleen_US

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