Is plasma atherogenic index or LDL/HDL ratio more predictive of peripheral arterial disease complexity?

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dc.authoridEvsen, Ali/0000-0002-3780-7137
dc.authoridaltunova, Mehmet/0000-0001-5351-5022
dc.contributor.authorEvsen, Ali
dc.contributor.authorAktan, Adem
dc.contributor.authorAltunova, Mehmet
dc.contributor.authorOzbek, Mehmet
dc.date.accessioned2025-02-22T14:08:50Z
dc.date.available2025-02-22T14:08:50Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The most basic and well-known cause of peripheral arterial disease (PAD) is atherosclerosis. One of the main factors causing atherosclerosis is dyslipidemia. We will evaluate whether specific ratios of dyslipidemia, such as the atherogenic plasma index (AIP) and LDL/HDL ratio, which have recently been used in practice, can help us to predict the complexity of PAD in the clinic. Methods: A total of 305 patients with PAD admitted to our clinic were retrospectively included in this study. After evaluation according to angiography images using TASC-II classification, patients were divided into TASC A-B and TASC C-D. AIP was evaluated with the following formula: Log (TG/HDL). Cut-off values for AIP and LDL/HDL were determined on the ROC (receiver operating characteristic) curve. Logistic regression analysis were conducted to predict peripheral arterial disease complexity. Results: The mean ages of Group 1 (n:180, 68.3% male) and Group 2 (n:125, 77.6% male) patients were 64.10 +/- 12.39 and 64.94 +/- 11.12 years, respectively. The prevalence of diabetes mellitus (DM, p < 0.016) and coronary artery disease (CAD, p < 0.001) was higher in group 2. Group 2 had higher TG (p = 0.045), LDL-C (p = 0.004), AIP (p = 0.010), LDL/HDL (p < 0.001), and lower HDL-C (p = 0.015). In multivariate logistic regression analysis evaluating parameters in predicting PAD complexity, DM (OR: 1.66 Cl 95%: 1.01-2.73 p = 0.045), CAD (OR: 2.86 Cl 95%: 1.75-4.69 p < 0.001) and LDL/HDL (OR: 1.47 Cl 95%: 1.10-1.96 p = 0.008) were independent variables. Conclusion: In our study, we compared LDL/HDL ratio and AIP in PAD for the first time in the literature and showed that LDL/HDL ratio is a more valuable ratio and an independent predictor of PAD complexity.en_US
dc.identifier.doi10.1177/17085381241260203
dc.identifier.issn1708-5381
dc.identifier.issn1708-539X
dc.identifier.pmid38862128en_US
dc.identifier.scopus2-s2.0-85196207484en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1177/17085381241260203
dc.identifier.urihttps://hdl.handle.net/11468/29666
dc.identifier.wosWOS:001247623600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofVascularen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectPeripheral arterial diseaseen_US
dc.subjectplasma atherogenic indexen_US
dc.subjectLDL/HDLen_US
dc.titleIs plasma atherogenic index or LDL/HDL ratio more predictive of peripheral arterial disease complexity?en_US
dc.typeArticleen_US

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