Omeprazole, nitrendipine, famotidine and stress-induced ulcers

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dc.contributor.authorInaloz, SS
dc.contributor.authorGoral, V
dc.contributor.authorSari, I
dc.contributor.authorCanberk, Y
dc.contributor.authorUlak, G
dc.date.accessioned2024-04-24T17:37:42Z
dc.date.available2024-04-24T17:37:42Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Omeprazole inhibits gastric acid secretion bq blocking the proton pump of the gastric parietal cell, Nitrendipine is a derivative of the dihydropyridine group of calcium channel blockers and administrated for angina and hypertension, Famotidine is one of the newer histamine H-2-receptor antagonists and heals gastric and duodenal ulcers by reducing gastric acid output, Objectives: The healing effects of omeprazole, nitrendipine and famotidine on stress-induced gastric ulcers were investigated in rats, Methods: Forty male Wistar-albino rats were separated into five groups (n = 8), a control (non-stress) and four experimental (stress) groups, Experimental rats were treated with omeprazole, nitrendipine, famotidine or a placebo after the stresses of starvation and coId-restraint, Result: Macroscopically, the mean area of the affected lesional mucosa was 1/4 of the total gastric mucosa in the famotidine treated group and 1/5 of the total gastric mucosa in the nitrendipine treated group. A considerably decrease was observed in the omeprazole treated group in which the mean area of the lesional mucosa was only in 1/8 of the total gastric mucosa, On microscopic examination, congestive vessels and chronic inflammatory cell infiltrates were significantly reduced in the omeprazole treated group, Tissue regeneration was more prominent in the omeprazole group than the other groups, Conclusion: Omeprazole was found to Ire superior in terms of the effect on the healing process to nitrendipine and famotidine. Although therapeutic effects of nitrendipine and famotidine were observed, those were less than omeprazole.en_US
dc.identifier.endpage196en_US
dc.identifier.issue3en_US
dc.identifier.pmid9396173
dc.identifier.scopus2-s2.0-0030710213
dc.identifier.scopusqualityQ3
dc.identifier.startpage192en_US
dc.identifier.urihttps://hdl.handle.net/11468/21135
dc.identifier.volume60en_US
dc.identifier.wosWOS:000072291600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAssoc Soc Scientifique Med Belgesen_US
dc.relation.ispartofActa Gastro-Enterologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamotidineen_US
dc.subjectNitrendipineen_US
dc.subjectOmeprazoleen_US
dc.subjectStress Ulceren_US
dc.titleOmeprazole, nitrendipine, famotidine and stress-induced ulcersen_US
dc.titleOmeprazole, nitrendipine, famotidine and stress-induced ulcers
dc.typeArticleen_US

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