Paraoxonase, total antioxidant activity and peroxide levels in marasmic children

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dc.contributor.authorEce, Aydın
dc.contributor.authorGurkan, Fuat
dc.contributor.authorCelik, Fatma
dc.contributor.authorBoşnak, Mehmet
dc.contributor.authorYel, Servet
dc.contributor.authorBalik, Hasan
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-04-24T16:11:02Z
dc.date.available2024-04-24T16:11:02Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to investigate the oxidant/antioxidant status, paraoxonase (PON) activity and leptin. levels in children with marasmic malnutrition. Design and methods: Thirty marasmic children (age 14.4 +/- 10.3. months) and 28 control subjects were included; Plasma PON activity, total antioxidant activity (TAO), total peroxide (TPX) and leptin,levels were measured. Results: Malnourished children had significantly. lower leptin.(3.6 +/- 1.1. vs. 11.8 +/- 4.5 ng/mL, P < 0.001), PON. activity (66.4 +/- 28.6 vs. 2213 +/- 31.6 IU/L, P < 0.001) and. TAO (1.44 +/- 0.12 vs. 2.45 +/- 0.61 mmol Trolox equiv/L, P < 0.001); and higher TPX (15.6 +/- 6.4 vs. 5.9 +/- 1.9 mu mol/L, P < 0.001) values than,in controls. Significant negative correlation was found between PON and TPX (P=0.040) and positive correlation between TAO and BMI (P= 0.034) in patients. No significant correlation was found between leptin and oxidam/antioxidant parameters (P > 0.05). Conclusions: Children with marasmic. malnutrition had increased. pro-oxidant and decreased antioxidant status. Extent of oxidative stress increases with malnutrition severity.. Antioxidants could be given during nutritional rehabilitation., (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiochem.2007.03.001
dc.identifier.endpage639en_US
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.issue9-10en_US
dc.identifier.pmid17433811
dc.identifier.scopus2-s2.0-34249681464
dc.identifier.scopusqualityQ2
dc.identifier.startpage634en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2007.03.001
dc.identifier.urihttps://hdl.handle.net/11468/15243
dc.identifier.volume40en_US
dc.identifier.wosWOS:000247289000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectLeptinen_US
dc.subjectMalnutritionen_US
dc.subjectParaoxonaseen_US
dc.subjectPeroxideen_US
dc.titleParaoxonase, total antioxidant activity and peroxide levels in marasmic childrenen_US
dc.titleParaoxonase, total antioxidant activity and peroxide levels in marasmic children
dc.typeArticleen_US

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