Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis

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dc.contributor.authorZachou, Kalliopi
dc.contributor.authorYurdaydin, Cihan
dc.contributor.authorDrebber, Uta
dc.contributor.authorDalekos, George N.
dc.contributor.authorErhardt, Andreas
dc.contributor.authorCakaloglu, Yilmaz
dc.contributor.authorDegertekin, Halil
dc.date.accessioned2024-04-24T17:11:36Z
dc.date.available2024-04-24T17:11:36Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Hepatitis delta virus (HDV) causes severe liver disease. Aims: To investigate the quantitative HDV-RNA, HBsAg and hepatitis B virus (HBV)DNA levels in correlation to histological, biochemical and demographical parameters in patients with chronic HDV infection as similar data in a large series of HDV patients are missing. Methods: Eighty HDV patients were recruited in Germany, Turkey and Greece; quantitative determination of HDV-RNA, HBsAg and HBV-DNA was performed by real-time polymerase chain reaction, the Architect HBsAg assay and Cobas TaqMan HBV test respectively. Results: All patients were infected with HDV-genotype 1. Thirty-five patients (48%) had significant fibrosis (Ishak 3-4) and 15 (20.5%) had cirrhosis. HDV viraemia ranged from 1.1 x 10(3) to 8.4 x 10(7) copies/ml with 60% of patients showing HDV-RNA levels above 105 copies/ml accompanied by low HBV viraemia (<10(5) copies/ml). However, HDV-RNA and HBV-DNA levels showed no direct inverse correlation. HDV-RNA correlated positively with HBsAg and negatively with age. HBsAg correlated negatively with age and positively with histological grading. Only gamma-glutamyltranspeptidase was independently associated with cirrhosis (P=0.032), while no biochemical parameter was associated with grading. Conclusions: (i) HBsAg levels correlated with HDV viraemia in chronic HDV. (ii) Biochemical parameters did not accurately indicate the stage and grade of liver disease in chronic HDV and thus liver biopsy seems to remain the major tool for the evaluation of delta hepatitis patients.en_US
dc.description.sponsorshipHep-Net Study House; German Ministry for Education and Research; F. Hoffmann-La Roche and Gilead Sciences; Hellenic (Greek) Association for the Study of the Liveren_US
dc.description.sponsorshipThis study was funded by the Hep-Net Study House (a national network sponsored by the German Ministry for Education and Research), F. Hoffmann-La Roche and Gilead Sciences. Dr H. Wedemeyer, Dr C. Yurdaydin and Dr M. P. Manns have received research grants, lecturer fees and travel support from F. Hoffmann-La Roche and Gilead Sciences. Dr G. N. Dalekos has received research grants, lecturer fees and travel support from Gilead Sciences Hellas Ltd and Roche (Hellas) S. A. Dr K. Zachou was supported by a scholarship from the Hellenic (Greek) Association for the Study of the Liver.en_US
dc.identifier.doi10.1111/j.1478-3231.2009.02140.x
dc.identifier.endpage437en_US
dc.identifier.issn1478-3223
dc.identifier.issn1478-3231
dc.identifier.issue3en_US
dc.identifier.pmid19840253
dc.identifier.scopus2-s2.0-77950615079
dc.identifier.scopusqualityQ1
dc.identifier.startpage430en_US
dc.identifier.urihttps://doi.org/10.1111/j.1478-3231.2009.02140.x
dc.identifier.urihttps://hdl.handle.net/11468/17624
dc.identifier.volume30en_US
dc.identifier.wosWOS:000273731500013
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofLiver International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Hepatitis Deltaen_US
dc.subjectHdv-Rnaen_US
dc.subjectPcren_US
dc.subjectQuantitative Hbsagen_US
dc.titleQuantitative HBsAg and HDV-RNA levels in chronic delta hepatitisen_US
dc.titleQuantitative HBsAg and HDV-RNA levels in chronic delta hepatitis
dc.typeArticleen_US

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