Possible lack of association between E469K polymorphism of ICAM-1 and non-obstructive azoospermia in south-east Turkey

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dc.authorid0000-0002-0589-9399en_US
dc.authorid0000-0002-3217-4246en_US
dc.authorid0000-0002-4446-0469en_US
dc.authorid0000-0001-5505-838Xen_US
dc.contributor.authorBalkan, Mahmut
dc.contributor.authorAkbaş, Halit
dc.contributor.authorPenbegül, Necmettin
dc.contributor.authorRüstemoglu, Aydın
dc.contributor.authorYücel, İlyas
dc.contributor.authorYıldız, İsmail
dc.date.accessioned2023-11-28T05:54:30Z
dc.date.available2023-11-28T05:54:30Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.description.abstractIntercellular adhesion molecule-1 (ICAM-1), a member of the large immunoglobulin superfamily of cell adhesion molecules, is a constituent component of the blood–testis barrier, and it plays a significant role in the homeostasis of spermatogenesis. The E469K polymorphism in the human ICAM-1 gene has been previously associated in various inflammatory/autoimmune disorders. However, the role of the ICAM-1 E469K polymorphism in spermatogenesis remains unclear. The aim of the present study is to analyse the possible association between the ICAM-1 E469K polymorphism and male infertility with non-obstructive azoospermia (NOA) patients within a group of men from Turkey. We included 111 infertile male with NOA and 114 fertile male as control subjects to the study. Genotyping was made by polymerase chain reaction–restriction fragment length polymorphism. The frequency of the genotype and the allele of ICAM-1 E469K were not significantly different between the control group and the patients (P > 0.05). This is the first study to investigate the role of the ICAM-1 gene polymorphism in male infertility with NOA. We conclude that the E469K polymorphism of ICAM-1 is not a risk factor for NOA in the Turkish population.en_US
dc.identifier.citationBalkan, M., Akbaş, H., Penbegül, N., Rüstemoğlu, A., Yücel, İ. ve Yıldız, İ. (2017). Possible lack of association between E469K polymorphism of ICAM-1 and non-obstructive azoospermia in south-east Turkey. Biotechnology and Biotechnological Equipment, 31(1), 143-147.en_US
dc.identifier.doi10.1080/13102818.2016.1261635
dc.identifier.endpage147en_US
dc.identifier.issn1310-2818
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85002301315
dc.identifier.scopusqualityQ3
dc.identifier.startpage143en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/13102818.2016.1261635
dc.identifier.urihttps://hdl.handle.net/11468/13052
dc.identifier.volume31en_US
dc.identifier.wosWOS:000390379500020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBalkan, Mahmut
dc.institutionauthorYücel, İlyas
dc.institutionauthorPenbegül, Necmettin
dc.institutionauthorYıldız, İsmail
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBiotechnology and Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzoospermiaen_US
dc.subjectE469Ken_US
dc.subjectICAM-1en_US
dc.subjectMale infertilityen_US
dc.subjectPolymorphismen_US
dc.titlePossible lack of association between E469K polymorphism of ICAM-1 and non-obstructive azoospermia in south-east Turkeyen_US
dc.titlePossible lack of association between E469K polymorphism of ICAM-1 and non-obstructive azoospermia in south-east Turkey
dc.typeArticleen_US

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