The association between the neutrophil/lymphocyte ratio and functional capacity in patients with idiopathic dilated cardiomyopathy

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dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorYuksel, Murat
dc.contributor.authorOylumlu, Mustafa
dc.contributor.authorPolat, Nihat
dc.contributor.authorAkil, Mehmet Ata
dc.contributor.authorAcet, Halit
dc.date.accessioned2024-04-24T17:25:03Z
dc.date.available2024-04-24T17:25:03Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The neutrophil/lymphocyte ratio (NLR) is an inexpensive, readily available and reliable inflammatory marker, which has a predictor value in different cardiovascular disorders. Functional capacity is one of the most important prognostic factors in patients with heart failure, which is usually stated as metabolic equivalents (MET). The goal of the study was to investigate the relationship between the NLR and functional capacity (FC) in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Treadmill test according to modified-Bruce protocol was performed in 37 patients with IDC (mean age 46.7 +/- 11.7 years, 81.1% male) to assess their functional capacity. Baseline clinical and echocardiographic variables were obtained. Hematological and biochemical parameters were measured using standard techniques. Results: The patients were divided into low (<5 MET, n=18) and high (>5 MET, n=19) FC groups according to their functional status in the exercise test. The 2 groups were similar regarding age, gender and the presence of hypertension and diabetes mellitus. There was no significant difference between groups regarding echocardiographic parameters such as left ventricular ejection fraction and diameters. However, the NLR was significantly higher in low FC group compared to high FC group (3.62 +/- 2.24 vs. 2.24 +/- 0.67, p=0.002; respectively). There were significant negative correlations between the NLR, MET and left ventricular ejection fraction (r=-0.405, p=0.013 and r=-0.028, p=0.028; respectively). Diastolic dysfunction was present in all the patients with low functional capacity. A cut-off point of 2.26 for the NLR had 83% sensitivity and 69% specificity in predicting poor FC. After multivariate analysis, only the NLR remained significant predictor of poor functional status. Conclusion: We detected a significant association between the NLR and low FC, both of which has predictive and prognostic value in patients with heart failure. Functional capacity may depend on diastolic function rather than left ventricular ejection fraction in patients with IDC.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.doi10.5152/akd.2014.5131
dc.identifier.endpage17en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue1en_US
dc.identifier.pmid25179880
dc.identifier.startpage13en_US
dc.identifier.trdizinid206245
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5131
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/206245
dc.identifier.urihttps://hdl.handle.net/11468/19918
dc.identifier.volume15en_US
dc.identifier.wosWOS:000348353200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIdiopathic Dilated Cardiomyopathyen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectHeart Failureen_US
dc.subjectFunctional Capacityen_US
dc.titleThe association between the neutrophil/lymphocyte ratio and functional capacity in patients with idiopathic dilated cardiomyopathyen_US
dc.titleThe association between the neutrophil/lymphocyte ratio and functional capacity in patients with idiopathic dilated cardiomyopathy
dc.typeArticleen_US

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