Leptin levels and lipoprotein profiles in patients with cholelithiasis

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dc.contributor.authorSarac, Serdar
dc.contributor.authorAtamer, Aytac
dc.contributor.authorAtamer, Yildiz
dc.contributor.authorCan, Ahmet Selcuk
dc.contributor.authorBilici, Aslan
dc.contributor.authorTacyildiz, Ibrahim
dc.contributor.authorKocyigit, Yuksel
dc.date.accessioned2024-04-24T17:14:34Z
dc.date.available2024-04-24T17:14:34Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis. Methods Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and haemoglobin A(1c) levels were recruited. Fasting blood samples from all study participants were assayed for glucose, haemoglobin A(1c,) total cholesterol, high density lipoprotein-cholesterol (HDL-C) and triglyceride. Serum Lp(a), ApoA-1 and ApoB levels were measured using nephelometric assays; serum leptin was measured using an enzyme-linked immunosorbent assay. Results A total of 90 patients with cholelithiasis and 50 controls were included in the study. Serum levels of leptin, Lp(a), total cholesterol, triglyceride and ApoB were significantly increased, and levels of ApoA-1 and HDL-C were significantly decreased, in patients with cholelithiasis compared with controls. Serum leptin in patients with cholelithiasis were significantly positively correlated with Lp(a) and ApoB and negatively correlated with ApoA-1. Conclusions Patients with cholelithiasis have higher leptin levels and an altered lipoprotein profile compared with controls, with increased leptin levels being associated with increased Lp(a) and ApoB levels, and decreased ApoA-1 levels, in those with cholelithiasis.en_US
dc.identifier.doi10.1177/0300060514561134
dc.identifier.endpage392en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue3en_US
dc.identifier.pmid25762517
dc.identifier.scopus2-s2.0-84930392602
dc.identifier.scopusqualityQ2
dc.identifier.startpage385en_US
dc.identifier.urihttps://doi.org/10.1177/0300060514561134
dc.identifier.urihttps://hdl.handle.net/11468/18067
dc.identifier.volume43en_US
dc.identifier.wosWOS:000354772600013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeptinen_US
dc.subjectCholelithiasisen_US
dc.subjectLipoproteinsen_US
dc.subjectLipoprotein(A)en_US
dc.subjectApolipoprotein A-1en_US
dc.subjectApolipoprotein Ben_US
dc.titleLeptin levels and lipoprotein profiles in patients with cholelithiasisen_US
dc.titleLeptin levels and lipoprotein profiles in patients with cholelithiasis
dc.typeArticleen_US

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