Prognostic value of the lymphocyte-to-monocyte ratio and other inflammatory markers in malignant pleural mesothelioma

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dc.authorid0000-0001-8168-136Xen_US
dc.contributor.authorTanrıkulu, Abdullah Çetin
dc.contributor.authorAbakay, Abdurrahman
dc.contributor.authorKömek, Halil
dc.contributor.authorAbakay, Özlem
dc.date.accessioned2024-04-03T13:07:38Z
dc.date.available2024-04-03T13:07:38Z
dc.date.issued2016en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjectives: Inflammation plays a role in malignant pleural mesothelioma (MPM) prognosis and symptoms. We investigated the roles of the new and old inflammatory indexes and markers in MPM prognosis. Methods: Two hundred and ninety-two MPM patients (167 male and 125 female) were included in this retrospective study. Demographic parameters were collected from the patients’ files. Kaplan–Meier curves and multivariate Cox regression analyses were used for the analysis of prognosis. Results: The mean age of the patients was 58.4 years. The mean survival time was 14.6 ± 13.0 months. Twenty-four potential prognostic factors associated with a poor outcome were calculated in the univariate analysis, and 16 potential prognostic factors were associated with a poor prognosis. These 16 potential prognostic factors were also analyzed in multivariate analysis. Multivariate analysis showed that increased age, stage 3–4 disease, the non-epithelial type, a low Karnofsky performance score, a high white blood cell count, and a low lymphocyte-to-monocyte ratio (LMR) were associated with a poor prognosis. The results of the multivariate analysis showed that a decreased LMR was associated with poor survival. Patients with LMR ≤2.6 had poor survival compared with those with LMR >2.6 (mean 9.6 vs. 17.0 months, respectively; p = 0.004). Conclusions: LMR is an independent marker of prognosis in patients with MPM and is superior to the other inflammation-based markers. The inexpensive nature and easy reproducibility of the hemogram should encourage the use of the LMR in clinical practice.en_US
dc.identifier.citationTanrıkulu, A. Ç., Abakay, A., Kömek, H. ve Abakay, Ö. (2016). Prognostic value of the lymphocyte-to-monocyte ratio and other inflammatory markers in malignant pleural mesothelioma. Environmental Health and Preventive Medicine, 21(5), 304-311.en_US
dc.identifier.doi10.1007/s12199-016-0530-6
dc.identifier.endpage311en_US
dc.identifier.issn1342-078X
dc.identifier.issue5en_US
dc.identifier.pmid27068290
dc.identifier.scopus2-s2.0-85046235030
dc.identifier.scopusqualityQ1
dc.identifier.startpage304en_US
dc.identifier.urihttps://environhealthprevmed.biomedcentral.com/articles/10.1007/s12199-016-0530-6
dc.identifier.urihttps://hdl.handle.net/11468/13819
dc.identifier.volume21en_US
dc.identifier.wosWOS:000381290400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTanrıkulu, Abdullah Çetin
dc.institutionauthorAbakay, Abdurrahman
dc.institutionauthorAbakay, Özlem
dc.language.isoenen_US
dc.publisherSpringer Tokyoen_US
dc.relation.ispartofEnvironmental Health and Preventive Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectLymphocyte-to-monocyte ratioen_US
dc.subjectMalignant mesotheliomaen_US
dc.subjectPrognosisen_US
dc.titlePrognostic value of the lymphocyte-to-monocyte ratio and other inflammatory markers in malignant pleural mesotheliomaen_US
dc.titlePrognostic value of the lymphocyte-to-monocyte ratio and other inflammatory markers in malignant pleural mesothelioma
dc.typeArticleen_US

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