Plasma Leptin, Adiponectin, Neuropeptide Y Levels in Drug Naive Children With ADHD

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dc.contributor.authorOzcan, Ozlem
dc.contributor.authorArslan, Muejgan
dc.contributor.authorGuengoer, Serdal
dc.contributor.authorYueksel, Tugba
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.date.accessioned2024-04-24T17:14:41Z
dc.date.available2024-04-24T17:14:41Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: ADHD is one of the most common childhood psychiatric disorders. Research indicates that there is some link between obesity/overweight and ADHD, though the mechanism of this association remains uncertain. It is the aim of the present study to explore the association between ADHD, obesity, and plasma leptin, neuropeptide Y (NPY), and adiponectin levels. Method: Thirty-six patients diagnosed with ADHD were included in the study. The control group consisted of 40 healthy children and adolescents who had similar age and gender features with the patient group. Plasma leptin, adiponectin, NPY levels were measured, and body mass index (BMI), weight for height, and standard deviation scores (SDS) of height, weight, and BMI were calculated. Results: No significant difference was found between patients and healthy children in terms of BMI and BMI percentile. Participants were classified into three groups according to their weight to height values. There was no significant difference between the two groups, but 10% of the control group and 30.6% of the ADHD group were classified as overweight, which was 3 times higher than the control group. The adiponectin plasma level was significantly lower and leptin/adiponectin (L/A) ratio was significantly higher in the ADHD group. There was no significant difference between serum NPY levels. In the ADHD group, the mean leptin plasma level was high, but was not statistically significant. Conclusion: We think that a low adiponectin level and high L/A ratio may be the underlying mechanism of the obesity in ADHD patients.en_US
dc.identifier.doi10.1177/1087054715587095
dc.identifier.endpage900en_US
dc.identifier.issn1087-0547
dc.identifier.issn1557-1246
dc.identifier.issue9en_US
dc.identifier.pmid26078399
dc.identifier.scopus2-s2.0-85049040553
dc.identifier.scopusqualityQ1
dc.identifier.startpage896en_US
dc.identifier.urihttps://doi.org/10.1177/1087054715587095
dc.identifier.urihttps://hdl.handle.net/11468/18135
dc.identifier.volume22en_US
dc.identifier.wosWOS:000436042600010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Attention Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectAdiponectinen_US
dc.subjectNpyen_US
dc.subjectAttention Deficit Hyperactivityen_US
dc.titlePlasma Leptin, Adiponectin, Neuropeptide Y Levels in Drug Naive Children With ADHDen_US
dc.titlePlasma Leptin, Adiponectin, Neuropeptide Y Levels in Drug Naive Children With ADHD
dc.typeArticleen_US

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