Serum levels of leptin, insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with pre-eclampsia, and their relationship to insulin resistance

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dc.contributor.authorKocyigit, Y
dc.contributor.authorBayhan, G
dc.contributor.authorAtamer, A
dc.contributor.authorAtamer, Y
dc.date.accessioned2024-04-24T16:24:43Z
dc.date.available2024-04-24T16:24:43Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study was carried out to compare serum levels of leptin, insulin-like growth factor- I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3), homeostasis model assessment-(pancreatic beta-cell function) (HOMA-(%B)) and homeostasis model assessment-(tissue insulin sensitivity) (HOMA-(%S)) in women with mild and severe pre-eclampsia and normotensive pregnant women; and to evaluate the possible relationships between these Parameters in the pathogenesis of pre-eclampsia. Seventy-three women were divided into three groups: group A consisted of 20 normotensive pregnant women (NPW); group B consisted of 25 women with mild pre-eclampsia (MPE); and group C consisted of 28 women with severe pre-eclampsia (SPE). Serum level of leptin was measured by enzyme immunoassay using a commercial kit. Serum levels of IGF-I and IGFBP-3 were measured with a two-site immunoradiometric assay. Serum level of insulin was measured by the electrochemiluminescence immunoassay method. HOMA used indices of pancreatic beta-cell function and tissue insulin sensitivity. Differences between groups were compared by one-way analyses of variance and the post hoc Tukey-HSD test fir multiple comparisons; however, when a variable was not normally distributed, the Mann-Whitney U test was used. Associations between variables were tested using Pearson's coefficient of correlation. Birth weight was significantly lower (p < 0.001) in the MPE and SPE groups than in the NPW group. Serum levels of leptin and insulin in women with SPE and MPE were significantly higher (p < 0.001) than in NPW. Serum levels of IGF-I and IGFBP-3 were significantly lower in women with SPE and MPE compared with NPW (p < 0.001). The mean HOMA- (%B) level in women with SPE and MPF was significantly higher than in NPW (p < 0.001), whereas the mean HOMA-(%S) level in women with SPE and MPF was significantly lower than in NPW (p < 0.001). In the SPE group, systolic blood pressure correlated significantly with serum levels of IGF-I and leptin (r = 0.375, p < 0.05 and r = 0.495, p < 0.01, respectively). A negative correlation between, mean HOMA-(%S) level and serum IGFBP-3 level was noted (r =-0.357, p < 0.05). There was a positive correlation between serum level of IGF-I and mean HOMA-(%B) level in mildly pre-eclamptic women (r = 0.541, p < 0.01). We conclude that pre-eclampsia is associated with insulin resistance; and that existing hyperinsulinemia and insulin resistance in women with pre-eclampsia seem not to correlate with leptin and birth weight, but may correlate positively with IGF-I and IGFBP-3. Therefore we think that hyperleptinemia, low IGF-I or IGFBP-3, and insulin resistance may contribute to the pathogenesis of pre-eclampsia.en_US
dc.identifier.doi10.1080/09513590410001704975
dc.identifier.endpage348en_US
dc.identifier.issn0951-3590
dc.identifier.issue6en_US
dc.identifier.pmid15497497
dc.identifier.scopus2-s2.0-3142741781
dc.identifier.scopusqualityQ2
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.1080/09513590410001704975
dc.identifier.urihttps://hdl.handle.net/11468/16830
dc.identifier.volume18en_US
dc.identifier.wosWOS:000222689000007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherParthenon Publishing Groupen_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIgf-Ien_US
dc.subjectIgfbp-3en_US
dc.subjectLeptinen_US
dc.subjectInsulin Resistanceen_US
dc.subjectHomeostasis Model Assessmenten_US
dc.subjectPre-Eclampsiaen_US
dc.titleSerum levels of leptin, insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with pre-eclampsia, and their relationship to insulin resistanceen_US
dc.titleSerum levels of leptin, insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with pre-eclampsia, and their relationship to insulin resistance
dc.typeArticleen_US

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