Effects of Atorvastatin on Smoking-Induced Alveolar Injury in Rat Lungs

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dc.contributor.authorYildiz, Tekin
dc.contributor.authorTasdemir, Serhan
dc.contributor.authorTunik, Selcuk
dc.contributor.authorAtes, Gungor
dc.contributor.authorTekes, Selahaddin
dc.contributor.authorKaplanoglu, Iskender
dc.contributor.authorTopcu, Fusun
dc.date.accessioned2024-04-24T16:11:15Z
dc.date.available2024-04-24T16:11:15Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Smoking is one of the most serious health care issues worldwide, as one third to one half of all people who smoke eventually use tobacco habitually. Chronic smoke exposure causes airway and lung parenchymal inflammation and the destruction of alveolar cell walls. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage associated with smoking. OBJECTIVE: The aim of this study was to investigate whether atorvastatin protects against smoking-induced inflammation in alveolar epithelial type I (ATI) and type II (ATII) cells in the lungs of rats. METHODS: Adult male albino Wistar rats (200-250 g) were randomly divided into 3 groups and exposed to cigarette smoke 8 hours per day for 15 days. During that 15-day period, the 2 treatment groups received atorvastatin 0.5 or 1.0 mg/kg/d in 2 mL of methyl cellulose solution and the control group received 2 mL of methyl cellulose solution alone, all via nasogastric catheter. After the 15 days, the lungs were excised and the tissues were examined by transmission electron microscopy. RESULTS: Thirty rats were divided into 3 groups of 10 rats each. All rats survived the 15 days. In the atorvastatin 0.5-mg group, no changes were found in the ATI cells or in the blood-air barrier. In the atorvastatin 1.0-mg group, we observed hyperplasia in the common basal membranes. Hypertrophy, mitochondrial crystolysis (MC), and intracytoplasmic edema (ICE) were detected in the ATI cells in the 1.0-mg group, while chromatin condensation, atrophic appearance, cell shrinkage, and cytoplasmic vacuolization were observed in the ATII cells. The rough endoplasmic reticulum (rER) tubules of the ATII cells appeared spiral-shaped. In the control group, minimal ICE was detected in the ATI cells. However, microvillus deformation, pseudopod formation, edema, mitochondrial swelling, and MC were observed in the ATII cells. We also observed MC, several pinocytic vesicles, and normal rER tubules in the endothelial cells of the control group. CONCLUSIONS: The administration of atorvastatin 0.5 mg/kg/d was associated with some attenuation of lung injury caused by smoke inhalation in these rat lungs. However, atorvastatin 1.0 mg/kg/d was associated with lung damage. Future studies are needed to evaluate the dose-response relationship of atorvastatin to smoking-induced alveolar damage. (Curr Ther Res Clin Exp. 2009;70:366-376) (C) 2009 Excerpta Medica Inc.en_US
dc.identifier.doi10.1016/j.curtheres.2009.10.003
dc.identifier.endpage376en_US
dc.identifier.issn0011-393X
dc.identifier.issue5en_US
dc.identifier.pmid24683245
dc.identifier.scopus2-s2.0-71549138059
dc.identifier.scopusqualityQ3
dc.identifier.startpage366en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2009.10.003
dc.identifier.urihttps://hdl.handle.net/11468/15324
dc.identifier.volume70en_US
dc.identifier.wosWOS:000271608700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimental
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLungen_US
dc.subjectAtorvastatinen_US
dc.subjectUltrastructural Changesen_US
dc.subjectRaten_US
dc.titleEffects of Atorvastatin on Smoking-Induced Alveolar Injury in Rat Lungsen_US
dc.titleEffects of Atorvastatin on Smoking-Induced Alveolar Injury in Rat Lungs
dc.typeArticleen_US

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