The Possible Role of XRCC1 Gene Polymorphisms with Idiopathic Non-obstructive Azoospermia in Southeast Turkey

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dc.contributor.authorAkbas, Halit
dc.contributor.authorBalkan, Mahmut
dc.contributor.authorBinici, Mahir
dc.contributor.authorGedik, Abdullah
dc.date.accessioned2024-04-24T17:18:37Z
dc.date.available2024-04-24T17:18:37Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: X-ray repair cross-complementing group I (XRCC1) plays a role in repairing DNA damage during spermatogenesis. We examined the effects the possible role of two single nucleotide polymorphisms of XRCC1 Arg194Trp and Arg399Gln in DNA repair gene XRCC1 with risk of idiopathic non-obstructive azoospermia (INOA) in a south-east Turkey population. Materials and Methods: The genotype and allele frequencies of two observed polymorphisms of XRCC1 Arg194Trp and Arg399Gln were examined by polymerase chain reaction-restriction fragment length polymorphism in 102 infertile men with INOA and 102 fertile controls. Result: In our study, all the observed genotype frequencies were in agreement with Hardy-Weinberg equilibrium. The genotype frequencies of the XRCC Arg194Trp were 84% (CC), 16% (CT) and 2% (TT) among the men with INOA, while the frequencies of those genotypes in the controls were found to be 88% (CC), 12% (CT) and 2% (TT) (P < .05). Similarly, the genotypes frequencies of GG, GA, and AA of the XRCC1 Arg399Gln were 44%, 39%, and 19% in the group of men with INOA, whereas these frequencies were 42%, 45%, and 15% in the control group, respectively. No significant difference between the control group and the men with INOA were found in the frequencies of genotypes and allele of XRCC1 Arg194Trp and Arg399Gln (P > 0.05). Conclusion: Neither Arg194Trp nor Arg399Gln polymorphisms in the XRCC I gene influenced risk of INOA in our study. However, these findings may be helpful in improving the understanding of the etiology of male infertility.en_US
dc.identifier.doi10.22037/uj.v0i0.4435
dc.identifier.endpage385en_US
dc.identifier.issn1735-1308
dc.identifier.issn1735-546X
dc.identifier.issue4en_US
dc.identifier.pmid31004343
dc.identifier.scopus2-s2.0-85071705049
dc.identifier.scopusqualityQ3
dc.identifier.startpage380en_US
dc.identifier.urihttps://doi.org/10.22037/uj.v0i0.4435
dc.identifier.urihttps://hdl.handle.net/11468/18850
dc.identifier.volume16en_US
dc.identifier.wosWOS:000488149200012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUrol & Nephrol Res Ctr-Unrcen_US
dc.relation.ispartofUrology Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDna Repairen_US
dc.subjectIdiopathic Azoospermiaen_US
dc.subjectMale Infertilityen_US
dc.subjectSingle-Nucleotide Polymorphismen_US
dc.subjectXrcc1en_US
dc.titleThe Possible Role of XRCC1 Gene Polymorphisms with Idiopathic Non-obstructive Azoospermia in Southeast Turkeyen_US
dc.titleThe Possible Role of XRCC1 Gene Polymorphisms with Idiopathic Non-obstructive Azoospermia in Southeast Turkey
dc.typeArticleen_US

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