The investigation of the chemical composition and applicability of gold nanoparticles synthesized with amygdalus communis (Almond) leaf aqueous extract as antimicrobial and anticancer agents

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dc.authorid0000-0001-8133-6670en_US
dc.authorid0000-0003-3758-0654en_US
dc.authorid0000-0003-0274-4479en_US
dc.authorid0000-0001-7425-9718en_US
dc.authorid0000-0002-8684-1390en_US
dc.authorid0000-0003-4771-816Xen_US
dc.contributor.authorBaran, Mehmet Fırat
dc.contributor.authorKeskin, Cumali
dc.contributor.authorBaran, Ayşe
dc.contributor.authorEftekhari, Aziz
dc.contributor.authorOmarova, Sabina
dc.contributor.authorKhalilov, Rovshan
dc.contributor.authorAva, Canan Aytuğ
dc.date.accessioned2023-08-22T05:45:49Z
dc.date.available2023-08-22T05:45:49Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi Bilim ve Teknoloji Uygulama ve Araştırma Merkezien_US
dc.description.abstractThe current work’s main objective was to determine the chemical composition of Amygdalus communis (AC) leaf extract and examine the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs). The chemical composition of AC leaf extract was determined using LC-ESI/MS/MS to detect compounds that may be responsible for the reducing, stabilizing, and capping steps in the synthesis of nanoparticles and their biological activities. The AC-AuNPs were spherical, with a particle size lower than 100 nm and a face-centered cubic structure. The EDX spectrum confirmed the formation of AuNPs and a negative zeta potential value (−27.7 mV) suggested their physicochemical stability. The in vitro cytotoxic efficacy of the AC-AuNPs against colorectal adenocarcinoma (Caco-2), glioma (U118), and ovarian (Skov-3) cancer cell lines and human dermal fibroblasts (HDFs) was evaluated by MTT assay. CaCo-2 cell proliferation was effectively inhibited by the AC-AuNPs at concentrations between 25 and 100 g mL−1. The AC-AuNPs exerted preeminent antimicrobial activity against Bacillus subtilis with an MIC of 0.02 μg/mL, whilst good activity was shown against Staphylococcus aureus bacteria and Candida albicans yeast with an MIC of 0.12 μg/mL. Ultimately, the results support the high antibacterial and anticancer potential of biosynthesized AuNPs from AC leaf extract.en_US
dc.identifier.citationBaran, M. F., Keskin, C., Baran, A., Eftekhari, A., Omarova, S., Khalilov, R. ve diğerleri. (2023). The investigation of the chemical composition and applicability of gold nanoparticles synthesized with amygdalus communis (Almond) leaf aqueous extract as antimicrobial and anticancer agents. Molecules, 28(6), 1-19.en_US
dc.identifier.doi10.3390/molecules28062428
dc.identifier.endpage19en_US
dc.identifier.issn1420-3049
dc.identifier.issue6en_US
dc.identifier.pmid36985400
dc.identifier.scopus2-s2.0-85151114519
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/1420-3049/28/6/2428
dc.identifier.urihttps://hdl.handle.net/11468/12528
dc.identifier.volume28en_US
dc.identifier.wosWOS:000958118900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAva, Canan Aytuğ
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmygdalus communisLen_US
dc.subjectAnticanceren_US
dc.subjectAntimicrobialen_US
dc.subjectAuNPsen_US
dc.subjectChemical compositionen_US
dc.subjectGreen nanotechnologyen_US
dc.subjectNanomedicineen_US
dc.titleThe investigation of the chemical composition and applicability of gold nanoparticles synthesized with amygdalus communis (Almond) leaf aqueous extract as antimicrobial and anticancer agentsen_US
dc.titleThe investigation of the chemical composition and applicability of gold nanoparticles synthesized with amygdalus communis (Almond) leaf aqueous extract as antimicrobial and anticancer agents
dc.typeArticleen_US

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