Assessment of oxidative stress markers in cord blood of newborns to patients with oxytocin-induced labor

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dc.contributor.authorKaracor, Talip
dc.contributor.authorSak, Sibel
dc.contributor.authorBasaranoglu, Serdar
dc.contributor.authorPeker, Nurullah
dc.contributor.authorAgacayak, Elif
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorTurgut, Abdulkadir
dc.date.accessioned2024-04-24T17:11:45Z
dc.date.available2024-04-24T17:11:45Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: We aimed to measure the extent of oxidative stress experienced during labor by the neonates of pregnant women undergoing induced or spontaneous birth and to compare the effects of induced labor on fetalwell-being. Methods: Sixty-four healthy pregnant women referring to the Department of Gynecology and Obstetrics, Dicle University Medical Faculty between October 2010 and May 2011 were included in this comparative study. Pregnant women undergoing induced labor by oxytocin were group 1 and those without labor induction were group 2. Post-partum Apgar score was calculated at 1 and 5 min and measurements of weight and height of the neonateswere carried out. After the fetal cordwas clamped, 5 cm(3) blood was drawn into a plain tube without anticoagulant. The samples were centrifuged at 5000 r.p.m. for 5 min. Separated sera were transferred to Eppendorf tubes and were stored at -80 C degrees until the analysis time. Results: The complete blood counts and biochemistry results indicated that there were no statistically significant differences in regards to diseases between the two groups. Nitric oxide and asymmetrical dimethylarginine values of the two groups were not significantly different; however, there were statistically significant differences in the malondialdehyde, paraoxonase, total antioxidative status, and total oxidative status values of the two groups (respectively, P = 0.005, P = 0.006, P = 0.008, and P = 0.007). Conclusion: We observed that oxytocin-induced labor increases stress markers but does not affect Apgar scores. Oxidative stress in pregnant women may trigger antioxidative mechanisms. Prospective studies in larger cohorts are needed to better understand the impact of oxytocin-induced labor on pregnant women and neonates.en_US
dc.identifier.doi10.1111/jog.13263
dc.identifier.endpage865en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue5en_US
dc.identifier.pmid28759172
dc.identifier.scopus2-s2.0-85019580371
dc.identifier.scopusqualityQ2
dc.identifier.startpage860en_US
dc.identifier.urihttps://doi.org/10.1111/jog.13263
dc.identifier.urihttps://hdl.handle.net/11468/17702
dc.identifier.volume43en_US
dc.identifier.wosWOS:000403217900011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApgar Scoresen_US
dc.subjectDeliveryen_US
dc.subjectNewbornen_US
dc.subjectOxidative Stressen_US
dc.subjectOxytocin Inductionen_US
dc.titleAssessment of oxidative stress markers in cord blood of newborns to patients with oxytocin-induced laboren_US
dc.titleAssessment of oxidative stress markers in cord blood of newborns to patients with oxytocin-induced labor
dc.typeArticleen_US

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