Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication

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dc.contributor.authorYazgan, U. C.
dc.contributor.authorElbey, B.
dc.contributor.authorKuAY, S.
dc.contributor.authorBaykal, B.
dc.contributor.authorKeskin, I.
dc.contributor.authorYilmaz, A.
dc.contributor.authorSahin, A.
dc.date.accessioned2024-04-24T16:02:34Z
dc.date.available2024-04-24T16:02:34Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractMethanol toxicity is one of the major public health problems because it can cause severe morbidity and mortality. Methanol intoxication causes changes in the balance between the production of free radicals and antioxidant capacity. We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on the total oxidant status, total antioxidant status (TAS), and oxidative stress index (OSI) parameters of the liver and the serum in a rat model of acute methanol intoxication. Rats were treated with intraperitoneal (i.p.) Methotrexate (MTX) for 7 days. On the 8th day, i.p. Methanol was administered in the methanol, ethanol and CAPE groups. Four hours after methanol treatment, ethanol was injected i.p. in the ethanol group; CAPE (i.p.) in the CAPE group; serum physiologic i.p. in other groups. After 8 hours, rats were killed and the serum and the liver samples were obtained for biochemical analyses. The OSI value was significantly higher in the methanol group compared to the ethanol and CAPE groups. Serum TAS levels of the methanol group were significantly different compared to the control group, but not compared to the MTX group. The amelioration of oxidative stress was greater in the CAPE group compared to the ethanol group but was not statistically significant. This study demonstrates that CAPE treatment ameliorates oxidative stress in the serum and liver in a rat model of acute methanol intoxication.en_US
dc.identifier.doi10.1007/s11845-016-1462-2
dc.identifier.endpage523en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue2en_US
dc.identifier.pmid27139198
dc.identifier.scopus2-s2.0-84965002285
dc.identifier.scopusqualityQ1
dc.identifier.startpage519en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-016-1462-2
dc.identifier.urihttps://hdl.handle.net/11468/14841
dc.identifier.volume186en_US
dc.identifier.wosWOS:000401428700045
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCapeen_US
dc.subjectMethanol Intoxicationen_US
dc.subjectOxidant Stress Indexen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleEffect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxicationen_US
dc.titleEffect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication
dc.typeArticleen_US

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