The comparison of FOLFOX regimens with different doses of 5-FU for the adjuvant treatment of colorectal cancer: a multicenter study

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dc.authorid0000-0003-0882-0524en_US
dc.authorid0000-0001-7336-871Xen_US
dc.authorid0000-0003-3878-988Xen_US
dc.authorid0000-0002-7451-7286en_US
dc.contributor.authorAkdeniz, Nadiye
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorUncu, Doğan
dc.contributor.authorİnanç, Mevlüde
dc.contributor.authorKaya, Serap
dc.contributor.authorDane, Faysal
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorDemirci, Ayşe
dc.contributor.authorBilici, Mehmet
dc.contributor.authorDurnalı, Ayse Gök
dc.contributor.authorKoral, Lokman
dc.contributor.authorŞendur, Mehmet Ali Nahit
dc.contributor.authorErol, Cihan
dc.contributor.authorTürkmen, Esma
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorLaçin, Şahin
dc.contributor.authorŞahinli, Hayriye
dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2022-05-31T08:52:12Z
dc.date.available2022-05-31T08:52:12Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalıen_US
dc.descriptionWOS:000617829700001
dc.descriptionPMID: 33586012
dc.description.abstractPurpose We aim to compare the efficiency and toxicity of three different 5-fluorouracil (5-FU) administration types in 5-FU, leucovorin, and oxaliplatin (FOLFOX) combination treatment for adjuvant therapy in colorectal cancer (CRC). Methods Five hundred and seventy patients with stage III colorectal carcinoma who received different FOLFOX regimens after curative resection were included. Patients were divided into three groups as FOLFOX-4, modified FOLFOX-6 (mFOLFOX-6), and mFOLFOX-4 for comparison of toxicity and disease-free survival (DFS) and overall survival (OS) times. Results Three-year DFS rates for FOLFOX-4, mFOLFOX-6, and mFOLFOX-4 groups were 65%, 72%, and 72%, respectively. Five-year OS rates for FOLFOX-4, mFOLFOX-6, and mFOLFOX-4 groups were 69%, 75%, and 67%, respectively. There was no statistically significant difference between the three treatment groups in terms of DFS and OS (p = 0.079, and p = 0.147, respectively). Among grade 1-2 adverse events (AE), thrombocytopenia, neuropathy, and stomatitis were more common in the mFOLFOX-6-treated group. The frequency of grade 1-2 nausea and vomiting were similar in mFOLFOX-6 (36.3% and 24%, respectively) and mFOLFOX-4 (32.4% and 24.7%, respectively) groups but were higher than that in the FOLFOX-4 (19.5% and 11.3%, respectively) group. Among the most common grade 3-4 AE, neutropenia (53.4%, 9%, and 13.5%, respectively) and diarrhea (10.5%, 2.2%, and 2.4, respectively) were more common in FOLFOX-4. The rate of anemia and febrile neutropenia was similar in treatment groups (p = 0.063, and p = 0.210, respectively). Conclusion In the adjuvant treatment of stage III CRC patients, three different 5-FU administration types in FOLFOX combination treatment can be used with similar efficiency and manageable toxicity.en_US
dc.identifier.citationAkdeniz, N., Kaplan, M.A., Uncu, D., İnanc, M., Kaya, S., Dane, F. ve diğerleri. (2021). The comparison of FOLFOX regimens with different doses of 5-FU for the adjuvant treatment of colorectal cancer: a multicenter study. International Journal of Colorectal Disease, 36(6), 1311-1319en_US
dc.identifier.doi10.1007/s00384-021-03888-9
dc.identifier.endpage1319en_US
dc.identifier.issn0179-1958
dc.identifier.issn1432-1262
dc.identifier.issue6en_US
dc.identifier.pmid33586012
dc.identifier.scopus2-s2.0-85101043431
dc.identifier.scopusqualityQ2
dc.identifier.startpage1311en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s00384-021-03888-9
dc.identifier.urihttps://hdl.handle.net/11468/9932
dc.identifier.volume36en_US
dc.identifier.wosWOS:000617829700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, Muhammet Ali
dc.institutionauthorKüçüköner, Mehmet
dc.institutionauthorUrakçı, Zuhat
dc.institutionauthorIşıkdoğan, Abdurrahman
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal of Colorectal Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdjuvant chemotherapyen_US
dc.subjectColorectal canceren_US
dc.subjectFOLFOX regimensen_US
dc.subjectStage IIIen_US
dc.titleThe comparison of FOLFOX regimens with different doses of 5-FU for the adjuvant treatment of colorectal cancer: a multicenter studyen_US
dc.titleThe comparison of FOLFOX regimens with different doses of 5-FU for the adjuvant treatment of colorectal cancer: a multicenter study
dc.typeArticleen_US

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