Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model

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dc.contributor.authorCevik, Muazez
dc.contributor.authorDemir, Tuncer
dc.contributor.authorKaradag, Cetin Ali
dc.contributor.authorKetani, Muzaffer Aydin
dc.contributor.authorCelik, Hakim
dc.contributor.authorKaplan, Davut Sinan
dc.contributor.authorBoleken, Mehmet Emin
dc.date.accessioned2024-04-24T16:15:18Z
dc.date.available2024-04-24T16:15:18Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the effectiveness of hyaluronic acid on the prevention of esophageal damage and stricture formation after experimental caustic (alkaline) esophageal injury in rats. Materials and Methods: Twenty-one Wistar albino rats were randomly divided into three groups. A caustic esophageal burn was created following the Gehanno model: Group 1 (n=7) underwent operation, but no injury; Group 2 (n=7) was injured and left untreated; and Group 3 (n=7) was injured and treated with hyaluronic acid, first topically and then orally by gavage (2 x 0.3 mL; 12.5 mg/mL for 7 days). The caustic esophageal burn was created by instilling 25% NaOH into the distal esophagus. All rats were euthanized on day 22 for evaluation. The efficacy of hyaluronic acid treatment was assessed histopathologically and biochemically via blood determination of the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and sulfhydryl group (SH) and lipid hydroperoxidase (LOOH) levels. Statistical analyses were performed. Results: Weight gain was significantly lower in Group 2 than in the other two groups (P<0.05). The mean stenosis index, histopathologic damage score, TAS, TOS, OSI, and SH and LOOH levels were higher in Group 2 than in the other two groups. The mean stenosis index, inflammation, TAS, SH and OSI in Group 2 were significantly different than those in the other two groups (P<0.05). Conclusion: Hyaluronic acid treatment is effective in treating damage and preventing strictures after caustic esophageal burn in rats. (c) 2013 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2012.08.015
dc.identifier.endpage723en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue4en_US
dc.identifier.pmid23583124
dc.identifier.scopus2-s2.0-84876217078
dc.identifier.scopusqualityQ1
dc.identifier.startpage716en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2012.08.015
dc.identifier.urihttps://hdl.handle.net/11468/15747
dc.identifier.volume48en_US
dc.identifier.wosWOS:000318681400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaustic Esophageal Burnen_US
dc.subjectHyaluronic Aciden_US
dc.subjectRaten_US
dc.subjectSodium Hydroxideen_US
dc.subjectStrictureen_US
dc.subjectTreatmenten_US
dc.titlePreliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat modelen_US
dc.titlePreliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model
dc.typeArticleen_US

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