Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population

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dc.contributor.authorYucel, Yavuz
dc.contributor.authorCoskun, Salih
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorOzdemir, Hasan H.
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorCim, Abdullah
dc.contributor.authorCamkurt, M. Akif
dc.date.accessioned2024-04-24T17:33:09Z
dc.date.available2024-04-24T17:33:09Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5 HT) and their respective receptors have been implicated in the patogenesis. Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Office (DUBAP) [10-TF-150]en_US
dc.description.sponsorshipThis research article is supported by Dicle University Scientific Research Projects Coordination Office (DUBAP, Project No: 10-TF-150).en_US
dc.identifier.doi10.9758/cpn.2016.14.3.250
dc.identifier.endpage255en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue3en_US
dc.identifier.pmid27489378
dc.identifier.scopus2-s2.0-84988432223
dc.identifier.scopusqualityQ2
dc.identifier.startpage250en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.2016.14.3.250
dc.identifier.urihttps://hdl.handle.net/11468/20473
dc.identifier.volume14en_US
dc.identifier.wosWOS:000381780000003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology and Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraine Disordersen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectReceptor, Serotonin, 5-Ht2cen_US
dc.subjectGenetic Association Studiesen_US
dc.subjectHeadacheen_US
dc.titleAssociation of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Populationen_US
dc.titleAssociation of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
dc.typeArticleen_US

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