Protective effect of curcumin on priapism and ischemia-reperfusion injury in rats

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dc.contributor.authorYilmaz, Y.
dc.contributor.authorTaken, K.
dc.contributor.authorAtar, M.
dc.contributor.authorErgun, M.
dc.contributor.authorSoylemez, H.
dc.date.accessioned2024-04-24T17:37:51Z
dc.date.available2024-04-24T17:37:51Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: We aimed to identify the oxidative stress effects of the ischemic priapism on cavernosal tissues and to assess the biochemical and histopathological effects of curcumin in rats. MATERIALS AND METHODS: 26 adult male Sprague Dawley rats were randomly divided into three groups. Group 1 (Control, n = 8): only penectomy was performed and 3 ml blood samples were obtained from the vena cava inferior (VCI). Group 2 (ischemia-reperfusion group; n=8): penectomy was performed after 1 hour ischemic priapism + 30 min reperfusion and 3 ml blood samples were obtained from the VCI. Group I I I (IR + CURC group, n = 10) : 200 mg/kg/day curcumin per orally before surgery for 7 days + penectomy after 1 hour ischemic priapism + 30 min reperfusion and 3 ml blood samples from the VCI. Total oxidant status (TAS), total ant ioxidant status (TAS) and paraoxonase (PON1) levels were measured. Tissue samples were investigated and scored histopathologically in terms of bleeding, edema and necrosis. RESULTS: TOS levels were higher (p = 0.002), and TAS levels were lower (p = 0.001) in the IR group compared to the control group. As a result of curcumin treatment, TAS levels were increased (p = 0.003), and TOS levels were decreased (p = 0.004) in the IR + CURC group compared to the IR group. In the treatment group (IR + CURC) TAS and TOS levels were similar to levels in the control group. PON1 levels were increased with ischemia-reperfusion (p = 0.21) and decreased with curcumin treatment (p = 0.53), however these changes were not statistically significant. There was no significant difference in the effects of curcumin on histopathological changes. CONCLUSIONS: This study showed that curcumin has preventive effects on oxidative stress parameters against ischemia-reperfusion injury.en_US
dc.identifier.endpage4670en_US
dc.identifier.issn1128-3602
dc.identifier.issue23en_US
dc.identifier.pmid26698266
dc.identifier.scopus2-s2.0-84966359464
dc.identifier.scopusqualityQ2
dc.identifier.startpage4664en_US
dc.identifier.urihttps://hdl.handle.net/11468/21216
dc.identifier.volume19en_US
dc.identifier.wosWOS:000369540900030
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPriapismen_US
dc.subjectOxidative Stressen_US
dc.subjectParaoxonaseen_US
dc.subjectCurcuminen_US
dc.subjectRatsen_US
dc.titleProtective effect of curcumin on priapism and ischemia-reperfusion injury in ratsen_US
dc.titleProtective effect of curcumin on priapism and ischemia-reperfusion injury in rats
dc.typeArticleen_US

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