Protective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat

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dc.contributor.authorSilfeler, Ibrahim
dc.contributor.authorAlp, Harun
dc.contributor.authorOzgur, Tumay
dc.contributor.authorEvlioglu, Osman
dc.contributor.authorCelik, Murat
dc.contributor.authorEr, Metin
dc.contributor.authorYilmaz, Gulsah
dc.date.accessioned2024-04-24T17:14:36Z
dc.date.available2024-04-24T17:14:36Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Paraquat (PQ; 1,1'dimethyl-bipyridilium 4,4'-dichloride), which is used extensively throughout the world, is highly toxic to humans. We aimed to investigate the protective effects of different doses of caffeic acid phenethyl ester (CAPE) on PQ-intoxicated rats. Materials and methods: A total of 80 rats were divided into the following eight groups, comprising 10 rats in each group: group 1: control; group 2: administered with CAPE (10 mu mol/kg); group 3: administered with 15 mg/kg PQ (PQ 15 group); group 4: administered with 30 mg/kg PQ (PQ30 group); group 5: administered with 45 mg/kg PQ (PQ45 group); group 6: administered with 15 mg/kg PQ CAPE; group 7: administered with 30 mg/kg PQ + CAPE and group 8: administered with 45 mg/kg PQ + CAPE. Both PQ and CAPE were injected intraperitoneally. Pancreatic tissue was examined with both haematoxylin and eosin and immunochemical staining. Results: The ratio of the immunohistochemical staining area to the total pancreatic area of the beta cells revealed that statistically significant differences were observed only between the PQ and PQ + CAPE groups (p < 0.05). Discussion: The evaluation of the data suggests that CAPE can be used to prevent acute effects of PQ intoxication.en_US
dc.identifier.doi10.1177/0748233713484658
dc.identifier.endpage1007en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue11en_US
dc.identifier.pmid23589406
dc.identifier.scopus2-s2.0-84945124774
dc.identifier.scopusqualityQ2
dc.identifier.startpage1000en_US
dc.identifier.urihttps://doi.org/10.1177/0748233713484658
dc.identifier.urihttps://hdl.handle.net/11468/18082
dc.identifier.volume31en_US
dc.identifier.wosWOS:000363351400005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectPancreasen_US
dc.subjectParaquaten_US
dc.titleProtective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquaten_US
dc.titleProtective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat
dc.typeArticleen_US

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