The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study
dc.contributor.author | Akdag, Mehmet | |
dc.contributor.author | Akkurt, Zeynep M. | |
dc.contributor.author | Gul, Aylin | |
dc.contributor.author | Ucmak, Derya | |
dc.contributor.author | Yilmaz, Beyhan | |
dc.contributor.author | Sengul, Engin | |
dc.contributor.author | Topcu, Ismail | |
dc.date.accessioned | 2024-04-24T17:38:24Z | |
dc.date.available | 2024-04-24T17:38:24Z | |
dc.date.issued | 2014 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | Purpose: The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks after treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears). Results: Th e di ff erences between the mean values of the pre- treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi fi cant (p< 0.05), but there was no signi fi cant di ff erence between the pretreatment and post- treatment values at 250 and 500 Hz frequencies (p> 0.05). The difference between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not significantly different (p> 0.05). Conclusion: Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin- induced neurophysiological alterations in hearing. | en_US |
dc.identifier.endpage | E107 | en_US |
dc.identifier.issn | 0147-958X | |
dc.identifier.issn | 1488-2353 | |
dc.identifier.issue | 2 | en_US |
dc.identifier.pmid | 24690417 | |
dc.identifier.scopus | 2-s2.0-84898659873 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | E102 | en_US |
dc.identifier.uri | https://hdl.handle.net/11468/21432 | |
dc.identifier.volume | 37 | en_US |
dc.identifier.wos | WOS:000334296500007 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Canadian Soc Clinical Investigation | en_US |
dc.relation.ispartof | Clinical and Investigative Medicine | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | [No Keyword] | en_US |
dc.title | The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study | en_US |
dc.title | The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study | |
dc.type | Article | en_US |