The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study

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dc.contributor.authorAkdag, Mehmet
dc.contributor.authorAkkurt, Zeynep M.
dc.contributor.authorGul, Aylin
dc.contributor.authorUcmak, Derya
dc.contributor.authorYilmaz, Beyhan
dc.contributor.authorSengul, Engin
dc.contributor.authorTopcu, Ismail
dc.date.accessioned2024-04-24T17:38:24Z
dc.date.available2024-04-24T17:38:24Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks after treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears). Results: Th e di ff erences between the mean values of the pre- treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi fi cant (p< 0.05), but there was no signi fi cant di ff erence between the pretreatment and post- treatment values at 250 and 500 Hz frequencies (p> 0.05). The difference between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not significantly different (p> 0.05). Conclusion: Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin- induced neurophysiological alterations in hearing.en_US
dc.identifier.endpageE107en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue2en_US
dc.identifier.pmid24690417
dc.identifier.scopus2-s2.0-84898659873
dc.identifier.scopusqualityQ2
dc.identifier.startpageE102en_US
dc.identifier.urihttps://hdl.handle.net/11468/21432
dc.identifier.volume37en_US
dc.identifier.wosWOS:000334296500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical studyen_US
dc.titleThe effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study
dc.typeArticleen_US

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