Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine

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dc.authorid0000-0003-0527-189Xen_US
dc.authorid0000-0003-0861-8588en_US
dc.contributor.authorDündar, Ahmet
dc.contributor.authorCafer, Vugar
dc.contributor.authorAslanhan, Hamza
dc.contributor.authorÖzdemir, Hasan Hüseyin
dc.contributor.authorYılmaz, Ahmet
dc.contributor.authorÇevik, Mehmet Uğur
dc.date.accessioned2023-08-04T10:50:30Z
dc.date.available2023-08-04T10:50:30Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalıen_US
dc.description.abstractBackground: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels.Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease.Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method.Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease.en_US
dc.identifier.citationDündar, A., Cafer, V., Aslanhan, H., Özdemir, H. H., Yılmaz, A. ve Çevik, M. U. (2023). Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine. Neurological Research, 45(2), 97-102.en_US
dc.identifier.doi10.1080/01616412.2022.2156125
dc.identifier.endpage102en_US
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue2en_US
dc.identifier.pmid36526441
dc.identifier.scopus2-s2.0-85144317539
dc.identifier.scopusqualityQ3
dc.identifier.startpage97en_US
dc.identifier.urihttps://www.tandfonline.com/doi/epdf/10.1080/01616412.2022.2156125?needAccess=true&role=button
dc.identifier.urihttps://hdl.handle.net/11468/12433
dc.identifier.volume45en_US
dc.identifier.wosWOS:000898515400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslanhan, Hamza
dc.institutionauthorYılmaz, Ahmet
dc.institutionauthorÇevik, Mehmet Uğur
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectVilip-1en_US
dc.subjectYKL-40en_US
dc.subjectLipocalin-2en_US
dc.subjectIL-23en_US
dc.subjectInflammationen_US
dc.titleIncreased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraineen_US
dc.titleIncreased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine
dc.typeArticleen_US

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