The use of thymoquinone in nephrotoxicity related to acetaminophen

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dc.contributor.authorAycan, Ilker Onguc
dc.contributor.authorTokgoz, Orhan
dc.contributor.authorTufek, Adnan
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorTurgut, Huseyin
dc.contributor.authorCelik, Feyzi
dc.date.accessioned2024-04-24T16:14:56Z
dc.date.available2024-04-24T16:14:56Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: We aimed to investigate efficacy of intraperitoneally administered Thymoquinone (TQ) in acetaminophen (APAP) induced renal toxicity. Material and method: Forty Wistar Albino rats were randomly divided into 4 groups of ten rats each. Control group was untreated group while rats in TQ group were treated with single dose TQ. In APAP group rats were treated with single dose acetaminophen. In TQ + APAP group TQ and APAP were administered respectively. Rats were sacrificed at 24th hour; urea, creatinine and nitric oxide levels were measured also malondialdehyde activity were assessed in renal tissue specimens. Tissue damage scores were recorded in histopathological assessment. Results: Urea and creatinine levels were found significantly higher in APAP group than control group (p < 0.003). Urea and creatinine levels in APAP + TQ treated group were significantly lower than APAP treated group (p < 0.01). Serum NO activity and tissue MDA levels were higher in APAP group than control group (p <= 0.002). In contrast to APAP treated group serum NO activity and tissue MDA levels were found significantly lower in TQ + APAP group (p <= 0.03). In APAP group significant histopathological change was found compared with control group (p <= 0.001) where there was no significant change between control and TQ treated groups (p > 0.05). In APAP group we found significantly higher tissue damage scores than control group (p <= 0.001). In APAP + TQ group lower tissue damage scores were found compared with APAP group (p <= 0.001) while higher scores were found compared with control group (p <= 0.001). Conclusion: We can conclude that TQ treatment has therapeutical effect in APAP induced nephrotoxicity in rats. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijsu.2014.11.020
dc.identifier.endpage37en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.pmid25447604
dc.identifier.scopus2-s2.0-84921502589
dc.identifier.scopusqualityQ1
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2014.11.020
dc.identifier.urihttps://hdl.handle.net/11468/15527
dc.identifier.volume13en_US
dc.identifier.wosWOS:000348666000007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectAcetaminophenen_US
dc.subjectNephrotoxicityen_US
dc.titleThe use of thymoquinone in nephrotoxicity related to acetaminophenen_US
dc.titleThe use of thymoquinone in nephrotoxicity related to acetaminophen
dc.typeArticleen_US

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