A useful marker in the assessment of remission and activation of disease in patients with rheumatoid arthritis: Serum human neutrophil peptides 1-3

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dc.contributor.authorOkcu, Mehmet
dc.contributor.authorOktayoglu, Pelin
dc.contributor.authorMete, Nuriye
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorCaglayan, Mehmet
dc.contributor.authorDagli, Abdullah Zubeyir
dc.contributor.authorNas, Kemal
dc.date.accessioned2024-04-24T17:20:41Z
dc.date.available2024-04-24T17:20:41Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: Rheumatoid arthritis (RA) is a chronic disease of unknown etiology. Various cellular and molecular immunological factors are involved in the pathophysiology of RA. Recent studies suggest that neutrophils and alpha-defensins released from the neutrophils assume significant roles in the pathogenesis of RA. The aim of this study was to investigate the potential association between serum alpha-defensin levels and disease activity, functional status, radiological damage and several laboratory parameters in patients with RA. MATERIALS AND METHODS: A total of 42 patients with established RA who presented to the outpatient clinics of rheumatology of Dicle University Hospital and 38 healthy control subjects were included in this study. Disease activity was assessed by using the Disease Activity Scale 28 (DAS28). Quality of life was assessed by using the Rheumatoid Arthritis Quality of Life (RAQoL) Questionnaire and the Nottingham Health Profile (NHP). Functional status was assessed by using the Stanford Health Assessment Questionnaire (HAQ). Laboratory examinations included the following tests: CBC, ESH, CRP, and HNP 1-3. RESULTS: Patients with an active disease exhibited higher HNP 1-3 levels compared to patients in remission. At a cut off value of 708 pg/ml, sensitivity and specificity of the tests for HNP 1-3 were 72% and 70.6%, respectively. CONCLUSION: In the present study, patients with an active disease had significantly higher serum HNP 1-3 levels compared to patients in remission. In this respect, serum HNP 1-3 can be a useful marker in the assessment of disease activity and remission in patients with RA.en_US
dc.identifier.doi10.3233/BMR-160743
dc.identifier.endpage1150en_US
dc.identifier.issn1053-8127
dc.identifier.issn1878-6324
dc.identifier.issue6en_US
dc.identifier.pmid29991120
dc.identifier.scopus2-s2.0-85058310160
dc.identifier.scopusqualityQ2
dc.identifier.startpage1145en_US
dc.identifier.urihttps://doi.org/10.3233/BMR-160743
dc.identifier.urihttps://hdl.handle.net/11468/19200
dc.identifier.volume31en_US
dc.identifier.wosWOS:000460934000017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofJournal of Back and Musculoskeletal Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectHuman Neutrophil Peptidesen_US
dc.subjectDisease Activityen_US
dc.titleA useful marker in the assessment of remission and activation of disease in patients with rheumatoid arthritis: Serum human neutrophil peptides 1-3en_US
dc.titleA useful marker in the assessment of remission and activation of disease in patients with rheumatoid arthritis: Serum human neutrophil peptides 1-3
dc.typeArticleen_US

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