Serum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunity

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dc.authorid0000-0001-9568-5767en_US
dc.contributor.authorŞimşek, Şeref
dc.contributor.authorYüksel, Tuǧba
dc.contributor.authorÇim, Abdullah
dc.contributor.authorKaya, Savaş
dc.date.accessioned2024-01-22T10:38:23Z
dc.date.available2024-01-22T10:38:23Z
dc.date.issued2016en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk ve Ergen Ruh Sağlığı Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Previous reports have described an association between autoimmunity and primary obsessive compulsive disorder. This study aimed to investigate any differences in the levels of T helper 1, 2, and 17 effector cell cytokines between obsessive compulsive disorder patients and the control group. Methods: The study included 34 children (23 males, 11 females), aged between 7 and 17 years, with a diagnosis of obsessive compulsive disorder prior to receiving treatment. The control group consisted of age- and gender-matched children. Study participants were assessed using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version, Children's Yale Brown Obsession Compulsion Scale, and Children's Depression Inventory. Cytokine serum concentrations were measured using the BD Cytometric Bead Array Human Th1/Th2/Th17 Cytokine Kit. Results: Interleukin-17A, tumor necrosis factor-α, and interleukin-2 levels were significantly higher in obsessive compulsive disorder patients, However, there was no correlation between T helper 1 and 17 cytokine profiles in the obsessive compulsive disorder group. The duration and severity of obsessive compulsive disorder symptoms were not significantly associated with interleukin-17A, interferon-gamma-γ, interleukin-10, interleukin-6, interleukin-4, and interleukin-2 levels. Interestingly, a negative correlation was found between tumor necrosis factor-α levels and Clinical Global Impression scores. Conclusions: These findings suggest, in some cases, obsessive compulsive disorder may develop on a background of autoimmunity, and interleukin-2, tumor necrosis factor-α, and interleukin-17A may play a role in these autoimmune processes. Therefore, we believe it is important to investigate for obsessive compulsive disorder symptoms in patients with autoimmune disease and, conversely, autoimmune diseases in obsessive compulsive disorder patients.en_US
dc.identifier.citationŞimşek, Ş., Yüksel, T., Çim, A. ve Kaya, S. (2016). Serum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunity. International Journal of Neuropsychopharmacology, 19(8), 1-6.en_US
dc.identifier.doi10.1093/ijnp/pyw027
dc.identifier.endpage6en_US
dc.identifier.issn1461-1457
dc.identifier.issue8en_US
dc.identifier.pmid27207913
dc.identifier.scopus2-s2.0-84989169835
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11468/13239
dc.identifier.volume19en_US
dc.identifier.wosWOS:000384654200009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞimşek, Şeref
dc.institutionauthorYüksel, Tuğba
dc.institutionauthorÇim, Abdullah
dc.institutionauthorKaya, Savaş
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofInternational Journal of Neuropsychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutoimmunityen_US
dc.subjectChildrenen_US
dc.subjectCytokineen_US
dc.subjectIL-17en_US
dc.subjectObsessive compulsive disorderen_US
dc.titleSerum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunityen_US
dc.titleSerum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunity
dc.typeArticleen_US

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