Panton-Valentine leukocidin in community and hospital-acquired Staphylococcus aureus strains

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dc.contributor.authorOzekinci, Tuncer
dc.contributor.authorDal, Tuba
dc.contributor.authorYanik, Keramettin
dc.contributor.authorOzcan, Nida
dc.contributor.authorCan, Sukran
dc.contributor.authorTekin, Alicem
dc.contributor.authorYildirim, Halil Ibrahim
dc.date.accessioned2024-04-24T17:07:45Z
dc.date.available2024-04-24T17:07:45Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractStaphylococcus aureus causes serious hospital-acquired (HA) and community-acquired (CA) infections. Skin and soft-tissue infections especially are sometimes caused by strains harbouring Panton-Valentine leukocidin (PVL). PVL belongs to a family of bi-component leukocidal toxins produced by staphylococci. It is a pore-forming toxin encoded by lukF-PV and lukS-PV. A total of 70 S. aureus strains: 38 (54%) methicillin-resistant (MRSA) and 32 (46%) methicillin-susceptible (MSSA), were isolated from patients admitted to Dicle University Hospital (Turkey). Identification of S. aureus and antibiotics-susceptibility testing were performed with PHOENIX 100. PVL genes and mecA genes were detected by polymerase chain reaction. Of the 70 studied strains, 36 ones (51%) were community acquired and 34 ones (49%) were hospital acquired . A total of 38 (54%) strains were positive for mecA (mecA(+)), of which 32 ones (84%) were HA. Of the mecA(-) strains, 30 (94%) were CA. Of the 70 studied strains, 12 (17%) strains were PVL+: 8 (22%) of the 36 CA strains and 4 (12%) of the 34 HA strains. Of the 12 PVL+ strains, 4 strains were mecA(+). The PVL positivity rate was 25% in MSSA, whereas 10.5% in MRSA. Of the overall PVL+ strains, seven strains were obtained from wounds; four ones from skin abscess; and one from blood culture. Taken together, the obtained results showed a substantial level of PVL genes in the studied region. Although PVL is known as a common virulence factor of CA MRSA, HA MRSA isolates in our study showed a considerable rate of PVL positivity.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Office (DUBAP) [12-TF-119]en_US
dc.description.sponsorshipThis research was supported by the Dicle University Scientific Research Projects Coordination Office (DUBAP) [grant number 12-TF-119].en_US
dc.identifier.doi10.1080/13102818.2014.976457
dc.identifier.endpage1094en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue6en_US
dc.identifier.pmid26019595
dc.identifier.scopus2-s2.0-84919771062
dc.identifier.scopusqualityQ3
dc.identifier.startpage1089en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2014.976457
dc.identifier.urihttps://hdl.handle.net/11468/16947
dc.identifier.volume28en_US
dc.identifier.wosWOS:000348931600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMssaen_US
dc.subjectStaphylococcus Aureusen_US
dc.subjectPanton-Valentine Leukocidinen_US
dc.subjectMrsaen_US
dc.titlePanton-Valentine leukocidin in community and hospital-acquired Staphylococcus aureus strainsen_US
dc.titlePanton-Valentine leukocidin in community and hospital-acquired Staphylococcus aureus strains
dc.typeArticleen_US

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