A mixed-apoptotic effect of Jurinea mesopotamica extract on prostate cancer cells: a promising source for natural chemotherapeutics

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dc.authorid0000-0002-9469-4757en_US
dc.authorid0000-0001-8911-7763en_US
dc.authorid0000-0002-9590-5237en_US
dc.authorid0000-0002-9292-2410en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0001-6548-7823en_US
dc.contributor.authorKoyuncu, İsmai̇l
dc.contributor.authorTemiz, Ebru
dc.contributor.authorŞeker, Fatma
dc.contributor.authorBalos, M. Maruf
dc.contributor.authorAkkafa, Feridun
dc.contributor.authorYüksekdağ, Özgür
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2024-04-05T11:13:25Z
dc.date.available2024-04-05T11:13:25Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThis research investigates the potential use of Jurinea mesopotamica Hand.-Mazz. (Asteraceae) in cancer treatment. In this study, a plant extract was prepared using all parts of J. mesopotamica, and its effect on the proliferation of cancer and normal cells was tested using the MTT method. It was found to have a selective cytotoxic effect on prostate cancer cells, with the lowest IC50 (half-maximal inhibitory concentration) of 10μg/mL found in the butanol extract (JMBE). The extract suppressed the proliferation of prostate cancer cells (67 %), disrupted organelle integrity (49 %), increased reactive oxidative stress (66 %), and triggered cell death (51 %). In addition, apoptotic gene expressions and protein levels increased, and the profile of amino acids related to energy metabolism was elevated. Based on LC–MS/MS results, the plant contained higher levels of flavonoids, including isoquercitrin, cosmosiin, astragalin, nicotiflorin, luteolin, and apigenin. These results suggest that J. mesopotamica has a selective effect on prostate cancer due to its high flavonoid content and might be a promising natural alternative for cancer treatment.en_US
dc.identifier.citationKoyuncu, İ., Temiz, E., Şeker, F., Balos, M. M., Akkaya, F., Yüksekdağ, Ö. ve diğerleri. (2023). A mixed-apoptotic effect of Jurinea mesopotamica extract on prostate cancer cells: a promising source for natural chemotherapeutics. Chemistry and Biodiversity, 21(2), e202301747en_US
dc.identifier.doi10.1002/cbdv.202301747
dc.identifier.issn1612-1872
dc.identifier.issue2en_US
dc.identifier.pmid38161146
dc.identifier.scopus2-s2.0-85182691228
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.202301747
dc.identifier.urihttps://hdl.handle.net/11468/13853
dc.identifier.volume21en_US
dc.identifier.wosWOS:001146578000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistry and Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectCancer treatmenten_US
dc.subjectFlavonoiden_US
dc.subjectJurinea mesopotamicaen_US
dc.subjectProstate canceren_US
dc.titleA mixed-apoptotic effect of Jurinea mesopotamica extract on prostate cancer cells: a promising source for natural chemotherapeuticsen_US
dc.titleA mixed-apoptotic effect of Jurinea mesopotamica extract on prostate cancer cells: a promising source for natural chemotherapeutics
dc.typeArticleen_US

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