Comparison of F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT in the staging and restaging of gastric adenocarcinoma

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dc.authorid0000-0002-7931-2941en_US
dc.contributor.authorGündoğan, Cihan
dc.contributor.authorKömek, Halil
dc.contributor.authorCan, Canan
dc.contributor.authorYıldırım, Özgen Ahmet
dc.contributor.authorKaplan, İhsan
dc.contributor.authorErdur, Erkan
dc.contributor.authorPoyraz, Kerem
dc.contributor.authorGüzel, Yunus
dc.contributor.authorOruç, Zeynep
dc.contributor.authorÇakabay, Bahri
dc.date.accessioned2021-12-29T09:42:05Z
dc.date.available2021-12-29T09:42:05Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Medikal Onkoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000728500900009
dc.descriptionPMID: 34661379
dc.description.abstractObjective In this study, we aimed to evaluate the diagnostic sensitivities of Ga-68-FAPI-04 PET/CT and F-18-FDG PET/CT in the primary tumor, and nodal, peritoneal and distant organ metastases of primary and recurrent gastric adenocarcinoma (GAc) with patient and lesion-based comparison. Materials and method Twenty-one patients with histopathologically proven newly diagnosed or recurrent GAc who underwent F-18-FDG and Ga-68-FAPI-04 imaging were included in the study. Both imaging techniques were evaluated visually according to the intensity of organ-based uptake. SUVmax and tumor-to-background ratio (TBR) values obtained from primary tumor/relapse and metastatic organs were compared statistically. Results Ga-68-FAPI-04 uptake was positive in all 15 newly diagnosed patients, while two patients among them who had mucinous and signet ring cell carcinoma did not exhibit F-18-FDG uptake. The sensitivity and specificity of Ga-68-FAPI-04 PET/CT in detecting primary gastric were 100%, while the sensitivity and specificity of F-18-FDG were 86.6 and 100%, respectively. Ga-68-FAPI-04 imaging revealed diffuse stomach uptake in seven patients, while F-18-FDG could only show two of them. The sensitivity and specificity of in-patient-based detection of lymph node metastases were 100 and 95.2%, respectively, while these values were 71.4 and 93.7%, respectively, for F-18-FDG. For peritoneal involvement Ga-68-FAPI-04 had a sensitivity and specificity of 100%, whereas F-18-FDG had a sensitivity of 40% and a specificity of 100%. Conclusion Ga-68-FAPI-04 PET/CT is an imaging modality with the potential of yielding more sensitive and specific findings F-18-FDG PET/CT. This modality may help avoid invasive diagnostic procedures that may be frequently required in GAc.en_US
dc.identifier.citationGündoğan, C., Kömek, H., Can, C., Yıldırım, Ö.A., Kaplan, İ., Erdur, E. ve diğerleri. (2022). Comparison of F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT in the staging and restaging of gastric adenocarcinoma. Nuclear Medicine Communications, 43(1), 64-72.en_US
dc.identifier.doi10.1097/MNM.0000000000001489
dc.identifier.endpage72en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue1en_US
dc.identifier.pmid34661379
dc.identifier.scopus2-s2.0-85121977117
dc.identifier.scopusqualityQ3
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/11468/8881
dc.identifier.volume43en_US
dc.identifier.wosWOS:000728500900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOruç, Zeynep
dc.language.isoenen_US
dc.publisherLippincott William & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectF-18-FDGen_US
dc.subjectGa-68-FAPIen_US
dc.subjectPETen_US
dc.subjectCTen_US
dc.subjectGastric adenocarcinomaen_US
dc.subjectPeritoneal metastasisen_US
dc.titleComparison of F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT in the staging and restaging of gastric adenocarcinomaen_US
dc.titleComparison of F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT in the staging and restaging of gastric adenocarcinoma
dc.typeArticleen_US

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