Interferon-? gene+874T -: A polymorphism is associated with tuberculosis and gamma interferon response

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dc.contributor.authorSallakci, Nilgun
dc.contributor.authorCoskun, Mesut
dc.contributor.authorBerber, Zafer
dc.contributor.authorGurkan, Fuat
dc.contributor.authorKocamaz, Halil
dc.contributor.authorUysal, Gulnar
dc.contributor.authorBhuju, Sabin
dc.date.accessioned2024-04-24T16:18:33Z
dc.date.available2024-04-24T16:18:33Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractInterferon-gamma is the most important cytokine in resistance to mycobacterial diseases and common variants of interferon-gamma gene could be related to tuberculosis susceptibility. We tested the hypothesis that the interferon-gamma+874T-A polymorphism is associated with tuberculosis disease, and affects the interferon-gamma reponse. We determined by pyrosequencing the distribution of the interferon-gamma+874T-4 polymorphism in a Turkish population of 319 patients with pulmonary tuberculosis, 42 children with severe forms of tuberculosis and 115 healthy donors. We also analysed whether any correlation exists between this polymorphism and interferon-y response to Mycobacterium tuberculosis antigens by ELISPOT in 58 pulmonary tuberculosis cases, and the results were analysed according to the genotypes. We found that the minor allele (T) frequency was significantly lower in patients with pulmonary tuberculosis when compared to controls (P = 0.024, OR = 0.7), a similarly significant decrease in the frequency of TT genotype was observed in patients with pulmonary tuberculosis, compared to the control group (P = 0.02, OR = 0.49). IFN-gamma responses to PPD antigen in TT genotype was found to be significantly higher than the AA group (P>0.001). Non-parametric correlation analysis of ELISPOT data showed significant reverse correlation in PPD, CFP10 and ESAT6 values and IFN-gamma +874 genotypes. These results show that the IFN-gamma +874T-A polymorphism is related to the IFN-gamma response and the magnitude of the response decreases during transition from TT- to TA and to AA genotypes. Our data suggest that similar to various Caucasian populations, in a Turkish population the IFN-gamma+874 T-A polymorphism is also associated with tuberculosis disease and affects the magnitude of the IFN-gamma response. (C) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.tube.2006.10.002
dc.identifier.endpage230en_US
dc.identifier.issn1472-9792
dc.identifier.issue3en_US
dc.identifier.pmid17276141
dc.identifier.scopus2-s2.0-34047245791
dc.identifier.scopusqualityQ2
dc.identifier.startpage225en_US
dc.identifier.urihttps://doi.org/10.1016/j.tube.2006.10.002
dc.identifier.urihttps://hdl.handle.net/11468/16163
dc.identifier.volume87en_US
dc.identifier.wosWOS:000246325000008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTuberculosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTuberculosisen_US
dc.subjectInterferon Gamma Gene+874t-A Polymorphism (Ifn-Y+874 T-A)en_US
dc.subjectElispoten_US
dc.subjectGamma-Interferonen_US
dc.titleInterferon-? gene+874T -: A polymorphism is associated with tuberculosis and gamma interferon responseen_US
dc.titleInterferon-? gene+874T -: A polymorphism is associated with tuberculosis and gamma interferon response
dc.typeArticleen_US

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