Effect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red-eared slider turtles (Trachemys scripta elegans)

Basit Öğe Kaydı
dc.contributor.authorCorum, Duygu D.
dc.contributor.authorCorum, Orhan
dc.contributor.authorAtik, Orkun
dc.contributor.authorFaki, Hatice E.
dc.contributor.authorAltan, Feray
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-04-24T17:11:47Z
dc.date.available2024-04-24T17:11:47Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effect of benzylpenicillin on the pharmacokinetics of acyclovir in red-eared slider turtles (Trachemys scripta elegans). Six clinically healthy red-eared slider turtles weighing 400 and 580 g were used for the study. Acyclovir (40 mg/kg) and benzylpenicillin (30 mg/kg) were administered intravenously to turtles. In the study, the cross-pharmacokinetic design (2 x 2) with a 30-day washout period was performed in two periods. Plasma concentrations of acyclovir were assayed using the high-performance liquid chromatography with fluorescence detection. Pharmacokinetic parameters were calculated by two-compartment open pharmacokinetic model. Following the administration of acyclovir alone, elimination half-life (t(1/2)(beta)), area under the plasma concentration-time curve (AUC), total clearance (Cl-T), and volume of distribution at steady-state (V-dss) were 20.12 hr, 1,372 hr * mu g/mL, 0.03 L hr(-1) kg(-1), and 0.84 L/kg, respectively. Benzylpenicillin administration increased t(1/2)(beta), AUC, and V-dss while decreased Cl-T of acyclovir. These results showed that benzylpenicillin changed the pharmacokinetics of acyclovir following simultaneous administration in turtles. However, further research is needed to determine molecular mechanism of interaction in turtle.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Kastamonu, Turkey [KU-BAP01/2018-66]en_US
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Kastamonu, Turkey, Grant/Award Number: KU-BAP01/2018-66en_US
dc.identifier.doi10.1111/jvp.12860
dc.identifier.endpage324en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue4en_US
dc.identifier.pmid32212341
dc.identifier.scopus2-s2.0-85082743520
dc.identifier.scopusqualityQ1
dc.identifier.startpage319en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.12860
dc.identifier.urihttps://hdl.handle.net/11468/17721
dc.identifier.volume43en_US
dc.identifier.wosWOS:000521469400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcycloviren_US
dc.subjectBenzylpenicillinen_US
dc.subjectPharmacokineticsen_US
dc.subjectTurtlesen_US
dc.titleEffect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red-eared slider turtles (Trachemys scripta elegans)en_US
dc.titleEffect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red-eared slider turtles (Trachemys scripta elegans)
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu