Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia

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dc.contributor.authorYazici, S.
dc.contributor.authorDemirtas, S.
dc.contributor.authorGuclu, O.
dc.contributor.authorKarahan, O.
dc.contributor.authorYavuz, C.
dc.contributor.authorCaliskan, A.
dc.contributor.authorMavitas, B.
dc.date.accessioned2024-04-24T17:14:34Z
dc.date.available2024-04-24T17:14:34Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to determine the relationship between oxidative stress markers and the duration of ischemia in rat mesenteric and peripheral ischemia models. Methods: Forty rats were divided into five equal groups, as follows: rats in Group I (control group) were sacrificed to determine the baseline characteristics of the serum markers; the superior mesenteric artery was clamped via a simple laparotomy to induce mesenteric ischemia in Groups II and III; the right common femoral artery was clamped to induce peripheral ischemia in Groups IV and V. Blood samples were taken at 2 (Groups II and IV) and 6 (Groups III and V) hours after these procedures. The serum total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI) and paraoxonase-I (PON-I) enzyme activities were evaluated in the samples obtained from each group. Results: The OSI level of the control group was 91.00+/-5.46 (mean +/- SD). The OSI levels taken 2 hours after the induction of mesenteric ischemia and peripheral ischemia were significantly higher (194.50+/-11.16 and 301.75+/-19.98, respectively (p<0.05)). However, these levels decreased to 151.88+/-17.02 (mesenteric ischemia) and 108.88+/-9.46 (peripheral ischennia) after 6 hours. The PON-I levels of Group III (mesenteric ischemia at 6 hours) (99.75+/-7.26), Group IV (peripheral ischemia at 2 hours) (96.88+/-4.09), and Group V (peripheral ischemia at 6 hours) (111.25+/-10.33) were slightly elevated over that of the control group (87.38+/-5.31). However, the PON-I level of Group 11 (mesenteric ischemia at 2 hours) (42.88+/-3.14) was lower than that of the other groups (p<0.05). Conclusion: Despite the increment of oxidative markers in early periods of ischemia (2nd hour), which was a hypoxic response of ischemic cells, they have decreased markedly in prolonged ischemia. This might have been caused by the opening of some collateral circulation or the destruction of the ischemic cells.en_US
dc.identifier.doi10.1177/0267659114524012
dc.identifier.endpage455en_US
dc.identifier.issn0267-6591
dc.identifier.issn1477-111X
dc.identifier.issue5en_US
dc.identifier.pmid24534888
dc.identifier.scopus2-s2.0-84925292804
dc.identifier.scopusqualityQ1
dc.identifier.startpage450en_US
dc.identifier.urihttps://doi.org/10.1177/0267659114524012
dc.identifier.urihttps://hdl.handle.net/11468/18059
dc.identifier.volume29en_US
dc.identifier.wosWOS:000342272200009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofPerfusion-Uk
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia Durationen_US
dc.subjectOsi Levelsen_US
dc.subjectPon-I Levelsen_US
dc.subjectOxidative Balanceen_US
dc.subjectNon-Cardiac Ischemiaen_US
dc.titleUsing oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemiaen_US
dc.titleUsing oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia
dc.typeArticleen_US

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