Potential prognostic role of immune system activation marker neopterin in patients with type 2 diabetes

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dc.contributor.authorÜnüvar, Songül
dc.contributor.authorTanrıverdi, Zübeyde
dc.contributor.authorAslanhan, Hamza
dc.date.accessioned2022-08-10T07:38:51Z
dc.date.available2022-08-10T07:38:51Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalıen_US
dc.description.abstractBackground: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-γ) activation. These include viral and bacterial infections, auto immune diseases, metabolic diseases, psychiatric disorders, tissue and organ rejections, and different malignancies. The aim of this study was to evaluate the role of neopterin as a prognostic biomarker in type 2 diabetes, which is a metabolic disease with a high worldwide prevalence. Methods: The study included a total of one hundred thirtynine individuals including one hundred and six patients admitted to a family medicine outpatient clinic and diagnosed with type 2 diabetes and thirty-three healthy volunteers. Serum neopterin concentrations were measured using the enzyme-linked immunosorbent assay. Results: Serum neopterin levels significantly increased in type 2 diabetes patients, compared to the control group (p<0.001). Conclusions: Early diagnosis of diabetes and determination of the appropriate therapeutic options are of utmost importance, as diabetes is also associated with other systemic diseases. The risk of developing secondary diseases is high in untreated patients. Our study results suggest that serum neopterin may be a useful biomarker in patients with type 2 diabetes.en_US
dc.identifier.citationÜnüvar, S., Tanrıverdi, Z. ve Aslanhan, H. (2018). Potential prognostic role of immune system activation marker neopterin in patients with type 2 diabetes. Journal of Medical Biochemistry, 37(4), 465-469.en_US
dc.identifier.doi10.2478/jomb-2018-0004
dc.identifier.endpage469en_US
dc.identifier.issn1452-8258
dc.identifier.issue4en_US
dc.identifier.pmid30584406
dc.identifier.scopus2-s2.0-85047093072
dc.identifier.scopusqualityQ3
dc.identifier.startpage465en_US
dc.identifier.urihttps://scindeks.ceon.rs/article.aspx?artid=1452-82581804465Q
dc.identifier.urihttps://hdl.handle.net/11468/10159
dc.identifier.volume37en_US
dc.identifier.wosWOS:000442543800009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslanhan, Hamza
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmune system activationen_US
dc.subjectInterferon-gammaen_US
dc.subjectMetabolic diseasesen_US
dc.subjectNeopterinen_US
dc.subjectType 2 diabetesen_US
dc.titlePotential prognostic role of immune system activation marker neopterin in patients with type 2 diabetesen_US
dc.titlePotential prognostic role of immune system activation marker neopterin in patients with type 2 diabetes
dc.typeArticleen_US

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