Assessment of serum asymmetric dimethylarginine levels and left ventricular diastolic function in patients with ankylosing spondylitis

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dc.contributor.authorInci, Umit
dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorTekbas, Ebru
dc.date.accessioned2024-04-24T17:11:24Z
dc.date.available2024-04-24T17:11:24Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To assess left ventricular diastolic functions and serum dimethylarginine (ADMA) concentrations, as well as the effect of different treatment strategies on ADMA concentrations and diastolic function parameters, in patients with ankylosing spondylitis (AS). Method: Sixty AS patients and 40 control subjects without classical cardiovascular (CV) risk factors were included in the study. Baseline clinical and echocardiographic variables were obtained. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and ADMA levels were measured. Spinal mobility, disease activity and functional status were assessed using Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index. Results: CRP, ESR and ADMA levels were significantly higher in the AS group as compared to the control group. Two (5%) control subjects and six (10%) AS patients met the criteria for left ventricular diastolic dysfunction (DD) on conventional Doppler echocardiography, but the difference was not statistically significant (P = 0.36). However, using tissue Doppler imaging, 12 (20%) patients in the AS group and three (8%) subjects in the control group were diagnosed with left ventricular DD (P = 0.08). The anti-tumor necrosis factor (TNF)-alpha group, conventional therapy group and control group were compared in terms of ADMA, CRP, ESR levels and echocardiographic parameters. ADMA levels were significantly lower in anti-TNF-alpha group as compared to the conventional therapy group (P < 0.001). In the control group, ADMA levels were significantly lower than both treatment groups (P < 0.001). Conclusion: Increased ADMA levels reveal impaired nitric oxide metabolism in a relatively young group of patients with AS, who have no classical CV risk factors. Anti-TNF-alpha may have beneficial effect on endothelial function in AS patients by reducing ADMA levels.en_US
dc.identifier.doi10.1111/1756-185X.12608
dc.identifier.endpage244en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue2en_US
dc.identifier.pmid26012572
dc.identifier.scopus2-s2.0-84930259792
dc.identifier.scopusqualityQ3
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12608
dc.identifier.urihttps://hdl.handle.net/11468/17479
dc.identifier.volume20en_US
dc.identifier.wosWOS:000402295100015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectAnti-Tnf-Alphaen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectDiastolic Functionen_US
dc.titleAssessment of serum asymmetric dimethylarginine levels and left ventricular diastolic function in patients with ankylosing spondylitisen_US
dc.titleAssessment of serum asymmetric dimethylarginine levels and left ventricular diastolic function in patients with ankylosing spondylitis
dc.typeArticleen_US

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