Formulation development of dual drug-loaded thermosensitive ocular in situ gel using factorial design

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dc.authorid0000-0001-5006-3091en_US
dc.authorid0000-0002-1518-010Xen_US
dc.authorid0000-0003-1786-4449en_US
dc.authorid0000-0002-7146-326Xen_US
dc.authorid0000-0002-0735-4229en_US
dc.contributor.authorPolat, Heybet Kerem
dc.contributor.authorArslan, Aslıhan
dc.contributor.authorÜnal, Sedat
dc.contributor.authorHaydar, Muhammet Kerim
dc.contributor.authorAytekin, Eren
dc.contributor.authorGözcü, Sefa
dc.contributor.authorMokhtare, Behzad
dc.date.accessioned2023-10-19T10:56:42Z
dc.date.available2023-10-19T10:56:42Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Patoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: To overcome the problems of low bioavailability of the drug associated with the short pre-corneal residence time, a thermoresponsive in situ gel system containing poloxamer P407, hydroxypropyl methylcellulose, and chitosan was developed to prolong the pre-corneal residence time of the drug. Methods: The central composite design was utilized to assess the effects of the concentration of poloxamer 407 hydroxypropyl methylcellulose and chitosan, the concentration of polymer, and the polymer type on the viscosity, pH, and gelation temperature, which were considered indicators of optimum formulations. Results: After model selection for response analysis, the quadratic model was found to be the best-fitting model for the relationship between independent factors and response variables. As a result of the central composite design, the optimized formulation contained 15.17% poloxamer 407 and 2.141% chitosan. Viscosity 25 °C = 2199.4 ± 26.2, viscosity 35 °C = 15,487.2 ± 117.4, pH = 6.5 ± 0.01, and gelation temperature °C = 33.3 ± 0.47 were obtained. The ex-vivo study revealed that the BRN formulation containing flurbiprofen-cyclodextrin inclusion complex has higher corneal penetration (P < 0.01). The cytotoxicity of ARPE-19 cells and irritation studies, as measured by in situ gel, was found to be acceptable. In lipoxygenase studies, the effectiveness of the BRN formulation was found to be significantly higher than other formulations (P < 0.01). Conclusions: It is thought that the BRN formulation may be an alternative to the treatment of ocular allergic disease.en_US
dc.identifier.citationPolat, H., K., Arslan, A., Ünal, S., Haydar, M. K., Aytekin, E., Gözcü, S. ve diğerleri. (2023). Formulation development of dual drug-loaded thermosensitive ocular in situ gel using factorial design. Journal of Pharmaceutical Innovation, 1-21.en_US
dc.identifier.doi10.1007/s12247-023-09762-1
dc.identifier.endpage21en_US
dc.identifier.issn1872-5120
dc.identifier.scopus2-s2.0-85167517359
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s12247-023-09762-1
dc.identifier.urihttps://hdl.handle.net/11468/12880
dc.identifier.volumeArticle in Pressen_US
dc.identifier.wosWOS:001045660900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMokhtare, Behzad
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Pharmaceutical Innovation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlurbiprofenen_US
dc.subjectQuercetinen_US
dc.subjectIn situ gelen_US
dc.subjectFactorial designen_US
dc.subjectCyclodextrinen_US
dc.subjectRelease kineticsen_US
dc.titleFormulation development of dual drug-loaded thermosensitive ocular in situ gel using factorial designen_US
dc.titleFormulation development of dual drug-loaded thermosensitive ocular in situ gel using factorial design
dc.typeArticleen_US

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