Immune mechanisms and the role of oxidative stress in intrahepatic cholestasis of pregnancy

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dc.contributor.authorOzler, Ali
dc.contributor.authorUcmak, Derya
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorElbey, Bilal
dc.contributor.authorArica, Mustafa
dc.contributor.authorKaya, Muhsin
dc.date.accessioned2024-04-24T17:24:52Z
dc.date.available2024-04-24T17:24:52Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The purpose of this study was to investigate levels of inflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and neopterin and oxidative stress status in patients with intrahepatic cholestasis of pregnancy (ICP) as well as their potential role in the pathophysiology. Material and methods: Thirty patients with ICP (Group 1) and 30 healthy pregnant women (Group 2) were included in this prospective case-control study. Levels of IL-6, TNF-alpha and neopterin were determined in both of the groups. Total anti-oxidant status (TAS) and total oxidative stress (TOS) levels were determined by means of a fully automated Erel method. Oxidative stress index (OSI) was calculated as the ratio of TOS to TAS. Results: There was no significant difference between the groups in IL-6 and TNF-alpha levels (p = = 0.105 and p = 0.722, respectively). The mean neopterin level was significantly higher in Group 1 compared to Group 2 (2.34 +/- 0.77 and 1.57 +/- 0.38, respectively, p = 0.001). In addition, TAS, TOS and OSI levels were significantly higher in Group I (p = 0.004, p = 0.001 and p = 0.001, respectively) compared to Group 2. Discussion: Intrahepatic cholestasis of pregnancy is an inflammatory disorder in which maternal immune reaction may play a role. Interleukin 6 and TNF-alpha, which are some of the markers of humoral reaction, act as an indicator of abnormal reaction rather than acute-phase reaction in ICP. Further clinical trials and supportive placental findings are needed on the role of cytokines in cellular and humoral immune reactions during the symptomatic period and delivery to better understand the role of immune mechanisms in the aetiology of ICP.en_US
dc.identifier.doi10.5114/ceji.2014.43723
dc.identifier.endpage202en_US
dc.identifier.issn1426-3912
dc.identifier.issn1644-4124
dc.identifier.issue2en_US
dc.identifier.pmid26155124
dc.identifier.scopus2-s2.0-84904512585
dc.identifier.scopusqualityQ3
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.5114/ceji.2014.43723
dc.identifier.urihttps://hdl.handle.net/11468/19860
dc.identifier.volume39en_US
dc.identifier.wosWOS:000338485000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofCentral European Journal of Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntrahepatic Cholestasis Of Pregnancyen_US
dc.subjectNeopterinen_US
dc.subjectInflammationen_US
dc.subjectInterleukinen_US
dc.subjectOxidative Stressen_US
dc.titleImmune mechanisms and the role of oxidative stress in intrahepatic cholestasis of pregnancyen_US
dc.titleImmune mechanisms and the role of oxidative stress in intrahepatic cholestasis of pregnancy
dc.typeArticleen_US

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