Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

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dc.contributor.authorKayabasi, Hasan
dc.contributor.authorSit, Dede
dc.contributor.authorAtay, A. Engin
dc.contributor.authorYilmaz, Zulfukar
dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorYilmaz, M. Emin
dc.date.accessioned2024-04-24T17:20:27Z
dc.date.available2024-04-24T17:20:27Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Quantity of oxidative stress (OS) is enhanced in every stage of chronic renal failure (CRF). OS and its effects on echocardiographic indexes in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Materials and methods: Thirty-nine patients on CAPD, 32 patients on HD, and 30 healthy individuals with similar demographic features were included. Patients with diabetes mellitus and chronic inflammatory diseases were excluded. Blood samples were collected to examine hematological and biochemical parameters and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and superoxide dismutase (SOD) after a 12-hour fasting period in the middle of dialysis week. OS parameters were compared with ejection fraction (EF), interventricular septum diameter (IVSd), left ventricular posterior wall diameter (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic examination. Results: No significant difference was observed between MDA and GSH-px levels of patients and control group; however, SOD levels of patients group were significantly lower (p < 0.0001). SOD levels of patients on HD were lower than that of patients on CAPD (p = 0.039). Negative correlation was detected between MDA and EF (r = -0.380, p = 0.001); SOD has negative correlation with systolic blood pressure (r = -0.265, p = 0.011), diastolic blood pressure (r = -0.230, p = 0.028), phosphorus (r = -0.327, p = 0.001), intact parathyroid hormone (iPTH) (r = -0.259, p = 0.013), C-reactive protein (CRP) (r = -0.235, p = 0.024), fibrinogen (r = -0.342, p = 0.001), and total cholesterol (r = -0.249, p = 0.017); and positive correlation with hemoglobin (r = 0.414, p < 0.001) and albumin (r = 0.367, p < 0.001). MDA was independently related with age (beta = -0.258, p = 0.035), male gender (beta = -0.312, p = 0.004), and EF (beta = -0.461, p < 0.001). No correlation was determined between antioxidants and cardiac indexes. Conclusion: SOD levels decreased significantly especially in patients on HD, and it was observed that lower levels of SOD would lead to OS in patients on HD and CAPD when compared to healthy individuals; MDA levels were independently influenced from EF.en_US
dc.identifier.doi10.3109/08860221003606299
dc.identifier.endpage334en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue3en_US
dc.identifier.pmid20370448
dc.identifier.scopus2-s2.0-77950563083
dc.identifier.scopusqualityQ2
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.3109/08860221003606299
dc.identifier.urihttps://hdl.handle.net/11468/19063
dc.identifier.volume32en_US
dc.identifier.wosWOS:000276364200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleParameters of oxidative stress and echocardiographic indexes in patients on dialysis therapyen_US
dc.titleParameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy
dc.typeArticleen_US

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