The effects of nonsteroidal anti-inflammatory drugs on platelet function and severity of upper gastrointestinal haemorrhage

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dc.contributor.authorPasa, Semir
dc.contributor.authorBayan, Kadim
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorTuzun, Yekta
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorCil, Timucin
dc.contributor.authorDanis, Ramazan
dc.date.accessioned2024-04-24T16:02:21Z
dc.date.available2024-04-24T16:02:21Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractNonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal (GI) damage primarily due to the inhibition of prostaglandin synthesis in gastric mucosa, which is an important factor in mucosa protection. Platelets are a cardinal feature of vascular repair. A variety of angiogenic stimulators are stored in platelets and are released during clotting at the wound. When there is a defect in any of these functions and/or platelet number, haemostasis is usually impaired and there may be an associated increased risk and severity of bleeding. While the mechanism of mucosal injury and bleeding are well documented with the use of NSAIDs, very little is known about the platelet function abnormalities and their effects on severity of upper GI bleedings. We performed a prospective analysis of 49 patients who had a history of NSAIDs use to investigate the association between the platelet function impairment associated with NSAIDs and severity of upper GI haemorrhages. Thirty-six of 49 patients (73.5%) had deteriorated platelet function. Mean severity score of patients with deteriorated platelet functions was 3.39, and that of patients with normal platelet functions was 2.46. Mean severity score was statistically significantly higher in patients with deteriorated platelet functions. In conclusion, impaired platelet functions associated with NSAIDs may cause more severe upper GI bleeding. Clinicians should be alert for GI complications especially in older patients and in those with a history of ulcer bleeding.en_US
dc.identifier.doi10.1007/s11239-008-0263-5
dc.identifier.endpage89en_US
dc.identifier.issn0929-5305
dc.identifier.issn1573-742X
dc.identifier.issue1en_US
dc.identifier.pmid18696215
dc.identifier.scopus2-s2.0-67449083792
dc.identifier.scopusqualityQ1
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1007/s11239-008-0263-5
dc.identifier.urihttps://hdl.handle.net/11468/14758
dc.identifier.volume28en_US
dc.identifier.wosWOS:000266911900015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Thrombosis and Thrombolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUpper Gastrointestinal Bleedingen_US
dc.subjectNonsteroidal Anti-Inflammatory Drugsen_US
dc.subjectPlatelet Function Testsen_US
dc.titleThe effects of nonsteroidal anti-inflammatory drugs on platelet function and severity of upper gastrointestinal haemorrhageen_US
dc.titleThe effects of nonsteroidal anti-inflammatory drugs on platelet function and severity of upper gastrointestinal haemorrhage
dc.typeArticleen_US

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