Mitochondrial miRNAs and fibromyalgia: new biomarker candidates

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dc.authorid0000-0002-9681-4468en_US
dc.authorid0000-0001-7939-5153en_US
dc.authorid0000-0001-8755-4812en_US
dc.contributor.authorKavak, Deniz Evrim
dc.contributor.authorDilek, Banu
dc.contributor.authorRasulova, Khayala
dc.contributor.authorPehlivan, Melek
dc.contributor.authorKızıldağ, Sefa
dc.date.accessioned2025-02-20T11:07:02Z
dc.date.available2025-02-20T11:07:02Z
dc.date.issued2025en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractntroduction / objective: Fibromyalgia syndrome (FMS), affecting 3–10% of the population, presents a challenge due to its complex symptomatology. Mitochondrial miRNAs (mitomiRs) are highlighted for their significant role in metabolic disorders. This study aimed to assess demographic data in Primer FMS patients and explore potential targets through mitomiR profiling. Methods: In our study, we examined 17 FMS patients and 18 controls, chosen based on specific criteria. Mitochondria were isolated from PBMCs in patient/control blood samples using the MACS method. Mitochondrial purity was verified through RT-qPCR and Western Blot. Following this, we extracted microRNAs and analyzed the levels of 3 mitochondrial miRNAs linked to oxidative stress (mitomiR-145-5p, mitomiR-23a-3p, mitomiR-223-3p) using RT-qPCR. Results: It was found that pain (P < 0.0001), fatigue (P = 0.0005), sleep quality (P < 0.0001), and depression (P < 0.0001) scores were significantly different in the FMS patient group compared to the control group. But the average BMI values have no difference compared to the control group (p = 0.7473). For the first time, a significant increase in mitomiR-145-5p was observed in the PBMCs of FMS patients compared to the control group (p = 0.0010). There was no significant difference observed in the gene expression levels of mitomiR-223-3p (p = 0.1623) and mitomiR-23a-3p (p = 0.4897). Conclusion: We demonstrated that mitomiR-145-5p plays a significant role in the progression of FMS pathology. Our study offers new insights, suggesting that mitochondrial miRNAs may have roles in FMS patients, which has not been previously investigated in the literature, thus providing a fresh perspective on the condition.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu TDK-2021-2615 Dokuz Eylul University 223S013en_US
dc.identifier.citationRasulova, K., Dilek, B., Kavak, D. E., Pehlivan, M. ve Kızıldağ, S. (2025). Mitochondrial miRNAs and fibromyalgia: new biomarker candidates. Molecular Biology Reports, 52(1), 1-8.en_US
dc.identifier.endpage8en_US
dc.identifier.issn0301-4851
dc.identifier.issue1en_US
dc.identifier.pmid39589649en_US
dc.identifier.scopus2-s2.0-85210452201en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11033-024-10110-w
dc.identifier.urihttps://hdl.handle.net/11468/29474
dc.identifier.volume52en_US
dc.identifier.wosWOS:001364756800004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorKavak, Deniz Evrim
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media B.V.en_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.isversionof10.1007/s11033-024-10110-wen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibromyalgiaen_US
dc.subjectMicroRNA (miRNA)en_US
dc.subjectMitochondriaen_US
dc.subjectMitochondria-associated miRNA (mitomiR)en_US
dc.titleMitochondrial miRNAs and fibromyalgia: new biomarker candidatesen_US
dc.typeArticleen_US

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