Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients

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dc.contributor.authorTurgut, A.
dc.contributor.authorOzler, A.
dc.contributor.authorGoruk, N. Y.
dc.contributor.authorTunc, S. Y.
dc.contributor.authorSak, M. E.
dc.contributor.authorEvsen, M. S.
dc.contributor.authorEvliyaoglu, O.
dc.date.accessioned2024-04-24T17:38:03Z
dc.date.available2024-04-24T17:38:03Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose of investigation: To investigate the roles of adipokines, free fatty acid (FFA), and oxidative stress in obese and non-obese preeclamptic patients. Materials and Methods: Gestational age-matched obese preeclamptic (n=32), non-obese preeclamptic (n=32),and non-obese normotensive healthy (n=32) pregnant women were included in the study. Serum insulin, insulin resistance, leptin, nesfatin, ghrelin, chemerin, FFA levels, total antioxidant status, total oxidant status, and oxidative stress index were determined. Results: Leptin and nesfatin levels were significantly lower and ghrelin levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptic groups. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics and normotensive group. Total antioxidant status (TAS) levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Total oxidative status (TOS) and oxidative stress index (OSI) levels were significantly lower in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Conclusion: Serum levels of adipokines, TOS, and FFAs were significantly higher in pregnants with preeclampsia as compared to non-obese normotensive controls. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics.en_US
dc.identifier.endpage479en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.pmid26411214
dc.identifier.scopus2-s2.0-84938561458
dc.identifier.scopusqualityQ4
dc.identifier.startpage473en_US
dc.identifier.urihttps://hdl.handle.net/11468/21303
dc.identifier.volume42en_US
dc.identifier.wosWOS:000359512600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectObesityen_US
dc.subjectFree Fatty Aciden_US
dc.subjectAdipokinesen_US
dc.titleSerum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patientsen_US
dc.titleSerum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients
dc.typeArticleen_US

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