Effect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats

Basit Öğe Kaydı
dc.contributor.authorAlemdar, Celil
dc.contributor.authorYucel, Istemi
dc.contributor.authorErbil, Baris
dc.contributor.authorErdem, Havva
dc.contributor.authorAtic, Ramazan
dc.contributor.authorOzkul, Emin
dc.date.accessioned2024-04-24T17:24:12Z
dc.date.available2024-04-24T17:24:12Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora. Materials and Methods: The rats were divided into three groups ( n = 15 per group) as follows: The IGF-1 group, HA group, and control group. An osteochondral defect of a diameter of 1.5 mm and a depth of 2 mm was created on the patellar joint side of femoral condyles. The IGF-1 group received an absorbable gelatin sponge soaked with 15 g/15 l of IGF-1, and the HA group received an absorbable gelatin sponge soaked with 80 g HA. The control group received only an absorbable gelatin sponge. Rats were sacrificed at the 6 (th) week, and the femur condyles were evaluated histologically. Results: According to the total Mankin scale, there was a statistically significant difference between IGF-1 and HA groups and between IGF-1 and control groups. There was also a significant statistical difference between HA and control groups. Conclusion: It was shown histopathologically that IGF-1 is an effective molecule for osteochondral lesions. Although it is weaker than IGF-1, HA also strengthened the repair tissue.en_US
dc.identifier.doi10.4103/0019-5413.185607
dc.identifier.endpage420en_US
dc.identifier.issn0019-5413
dc.identifier.issn1998-3727
dc.identifier.issue4en_US
dc.identifier.pmid27512224
dc.identifier.scopus2-s2.0-84979010125
dc.identifier.scopusqualityQ3
dc.identifier.startpage414en_US
dc.identifier.urihttps://doi.org/10.4103/0019-5413.185607
dc.identifier.urihttps://hdl.handle.net/11468/19513
dc.identifier.volume50en_US
dc.identifier.wosWOS:000381289600012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal of Orthopaedics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCartilageen_US
dc.subjectHyaluronic Aciden_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectOsteochondral Defect Mesh Terms: Hyaluronic Aciden_US
dc.subjectCartilageen_US
dc.subjectIgf-1en_US
dc.subjectSports Medicineen_US
dc.subjectRatsen_US
dc.titleEffect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in ratsen_US
dc.titleEffect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu