COMPARISON OF SKIP EXPRESSION IN MALIGNANT PLEURAL MESOTHELIOMAS WITH KI-67 PROLIFERATION INDEX AND PROGNOSTIC PARAMETERS

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dc.contributor.authorTurkcu, Gul
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorKeles, Ayse Nur
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorSen, Hatice Selimoglu
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T17:24:53Z
dc.date.available2024-04-24T17:24:53Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to determine the presence of SKI-interacting protein (SKIP) expression in malignant pleural mesothelioma (MPM) and its effect on prognosis by investigating SKIP correlation with the Ki-67 proliferation index and prognostic parameters. Pathological preparations of the patients diagnosed with MPM between 2006 and 2012 were evaluated. Immunohistochemical analyses were performed to evaluate the expression of SKIP and the Ki-67 proliferation index. Correlations between SKIP expression, clinicopathological factors and survival were investigated. Survival data were calculated using the Kaplan-Meier method, and Cox regression analysis was used to evaluate the prognostic value of the variables. In total, 52 patients were evaluated in the study; 36 of them were male and 16 were female. The mean age of the patients was 62.3 +/- 12.2 years. The median overall survival period was 8.5 months. Factors negatively affecting general survival in the univariate analysis included high SKIP expression, Ki-67 proliferative index over 30%, presence of non-epithelioid type MPM and stage III-IV disease (p < 0.05). Cox regression analysis revealed that high SKIP expression, high Ki-67 proliferative index and presence of non-epithelioid type MPM are independent factors that affect the survival rate. Higher SKIP expression is associated with poor prognosis in MPM.en_US
dc.identifier.doi10.5114/PJP.2016.61445
dc.identifier.endpage113en_US
dc.identifier.issn1233-9687
dc.identifier.issue2en_US
dc.identifier.pmid27543864
dc.identifier.scopus2-s2.0-84982992695
dc.identifier.scopusqualityQ4
dc.identifier.startpage108en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2016.61445
dc.identifier.urihttps://hdl.handle.net/11468/19869
dc.identifier.volume67en_US
dc.identifier.wosWOS:000383364900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesotheliomaen_US
dc.subjectSki-Interacting Protein (Skip)en_US
dc.subjectKi-67en_US
dc.subjectSurvivalen_US
dc.titleCOMPARISON OF SKIP EXPRESSION IN MALIGNANT PLEURAL MESOTHELIOMAS WITH KI-67 PROLIFERATION INDEX AND PROGNOSTIC PARAMETERSen_US
dc.titleCOMPARISON OF SKIP EXPRESSION IN MALIGNANT PLEURAL MESOTHELIOMAS WITH KI-67 PROLIFERATION INDEX AND PROGNOSTIC PARAMETERS
dc.typeArticleen_US

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