TP53 rs1042522 polymorphism and early-onset breast cancer

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dc.contributor.authorIcen-Taskin, Irmak
dc.contributor.authorIrtegun-Kandemir, Sevgi
dc.contributor.authorMunzuroglu, Omer
dc.date.accessioned2024-04-24T17:24:15Z
dc.date.available2024-04-24T17:24:15Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms. TP53 rs1042522 polymorphism relates to the risk of breast neoplasms, but this relationship in Turkish early-onset breast cancer patients has not been investigated yet. We aimed to search the relationship between TP53 rs1042522 polymorphism and young Turkish breast cancer patients. Materials and Methods: Ninety-six female breast cancer patients who were <= 40 years of age and 96 healthy controls were enrolled in our study. Participants were genotyped by the hybridization probe system. Results: We identified that the genotype frequencies of rs1042522 were significantly different between controls and cases (P = 0.027). Participants carrying CG genotype had also reduced breast cancer risk (odds ratio = 0.4196, 95% confidence interval: 0.1941-0.9067, P = 0.027). Our results revealed that there is an association between GG and CG + CC genotype groups with progesterone receptor (PgR) status (P = 0.0219). Conclusion: Our findings indicate that the CG genotype is a protective factor against breast neoplasms. No other clinicopathologic parameters except for PgR status were found to be related to rs1042522 polymorphism in young Turkish breast cancer patients.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Unit [MF.16.31]en_US
dc.description.sponsorshipThis work has been supported by Firat University Scientific Research Projects Unit with project number MF.16.31.en_US
dc.identifier.doi10.4103/jrms.JRMS_506_19
dc.identifier.issn1735-1995
dc.identifier.issn1735-7136
dc.identifier.pmid32419782
dc.identifier.scopus2-s2.0-85085173243
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.4103/jrms.JRMS_506_19
dc.identifier.urihttps://hdl.handle.net/11468/19565
dc.identifier.volume25en_US
dc.identifier.wosWOS:000613241400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Research in Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectEarly Onseten_US
dc.subjectGenotypeen_US
dc.subjectRs1042522en_US
dc.subjectTp53en_US
dc.titleTP53 rs1042522 polymorphism and early-onset breast canceren_US
dc.titleTP53 rs1042522 polymorphism and early-onset breast cancer
dc.typeArticleen_US

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